Evidence map›Paper›PMID 33590311›Full record

ArticlePsychopharmacology2021

Sex differences in effort-related decision-making: role of dopamine D2 receptor antagonism.

Emily L Errante, Marilyn Chakkalamuri, Oreoluwa I Akinbo, Samantha E Yohn, John D Salamone, Leslie Matuszewich

Abstract read
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In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily L ErranteDivision of Neuroscience and Behavior, Department of Psychology, Northern Illinois University, Dekalb, IL, 60115, USA.
Marilyn ChakkalamuriDivision of Neuroscience and Behavior, Department of Psychology, Northern Illinois University, Dekalb, IL, 60115, USA.
Oreoluwa I AkinboDivision of Neuroscience and Behavior, Department of Psychology, Northern Illinois University, Dekalb, IL, 60115, USA.
Samantha E YohnDepartment of Psychology, University of Connecticut, Storrs, CT, USA.
John D SalamoneDepartment of Psychology, University of Connecticut, Storrs, CT, USA.
Leslie MatuszewichDivision of Neuroscience and Behavior, Department of Psychology, Northern Illinois University, Dekalb, IL, 60115, USA. lmatusze@niu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleDepressed individuals demonstrate debilitating symptoms, including depressed mood, anhedonia, and effort-related deficits. Effort-related decision-making can be measured through providing subjects with a choice between high effort/reward and low effort/reward options, which is a dopamine (DA)-dependent behavior. While previous research has shown sex differences in depression rates, this has not been examined within operant-based effort-related decision-making tasks nor has DA been shown to underlie this behavior in female rats.

objectivesThe current study investigated sex differences in an effort-related decision-making task prior to and following administration of the DA D2 receptor antagonist haloperidol (HAL).

methodsAdult rats were food restricted or fed freely and trained in an effort-related progressive ratio choice task. After stable responding, HAL was administered acutely (0.05-0.2 mg/kg) prior to testing.

resultsResults indicate a significant effect of sex on training variables, with males having a greater number of lever presses, higher ratios, and longer active lever times. Pretreatment with HAL significantly reduced the same measures in both sexes for the high-valued reward, while increasing chow consumption in the food restricted males. Food restricted rats showed a greater number of total lever presses and achieved higher ratios; however, the effect in male food restricted rats was greatest.

conclusionsThese data suggest that, although there are sex differences in training, HAL decreases behavior across sexes, demonstrating that the D2 mechanism is similar in both sexes. These findings provide a better understanding of motivational dysfunction in both sexes and potential treatment targets for depression.

Indexed as

AnimalsChoice BehaviorDopamineDopamine D2 Receptor AntagonistsFemaleFoodHaloperidolMaleMotivationRatsRats, Sprague-DawleyReceptors, Dopamine D2RewardSex FactorsDopamineDopamine D2 Receptor AntagonistsHaloperidolReceptors, Dopamine D2Behavioral activationD2 receptorDepressionDopamineFood restrictionMotivationRewardSex differences

Identifiers

PMID33590311

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.