Evidence map›Paper›PMID 33590296›Full record

ReviewPflugers Archiv : European journal of physiology2021

Stress-driven cardiac calcium mishandling via a kinase-to-kinase crosstalk.

Charia McKee, Dan J Bare, Xun Ai

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Charia McKeeDepartment of Physiology & Biophysics, Rush University Medical Center, 1750 West Harrison St. 1255 Jelke, Chicago, IL, 60612-3825, USA.
Dan J BareDepartment of Physiology & Biophysics, Rush University Medical Center, 1750 West Harrison St. 1255 Jelke, Chicago, IL, 60612-3825, USA.
Xun AiDepartment of Physiology & Biophysics, Rush University Medical Center, 1750 West Harrison St. 1255 Jelke, Chicago, IL, 60612-3825, USA. Xun_Ai@rush.edu.ORCID http://orcid.org/0000-0003-0739-0286
Rush University Medical Center · US

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2000 to 2020
$42.4M
The Stress Response Kinase JNK and Alcohol Evoked Atrial FibrillationR01AA024769 · NIAAA · OHIO STATE UNIVERSITY · PI AI, XUN · 2017 to 2021
$3.3M
Heart-platelet crosstalk: JNK, AF, and thrombogenesisR01HL146744 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI Xun Ai, Yuchi Han · 2019 to 2026
$3.2M
Atrial and blood JNK in Postoperative AFR01HL168728 · NHLBI · OHIO STATE UNIVERSITY · PI Xun Ai · 2023 to 2026
$2.7M
JNK Suppression of Connexin43 Enhances Atrial Fibrillation in Aged AtriaR01HL113640 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AI, XUN · 2012 to 2015
$1.5M
NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R01 HL113640NHLBI NIH HHS R01 HL146744NHLBI NIH HHS R01 HL168728NIAAA NIH HHS R01 AA024769NIH HHS AA024769S2NIH HHS P01-HL06426NIH HHS R01-AA024769NIH HHS R01-HL113640NIH HHS R01-HL146744
6 · The paper itself

Abstract

Calcium homeostasis in the cardiomyocyte is critical to the regulation of normal cardiac function. Abnormal calcium dynamics such as altered uptake by the sarcoplasmic reticulum (SR) Ca

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingHumansMitogen-Activated Protein Kinase 9Myocytes, CardiacSarcoplasmic ReticulumCalcium-Calmodulin-Dependent Protein Kinase Type 2Mitogen-Activated Protein Kinase 9Ca2+/calmodulin-dependent protein kinase IICalcium handlingc-jun N-terminal kinaseDiastolic calcium leakSarcoplasmic reticulum

Identifiers

PMID33590296
PMCPMC7940337
OpenAlexW3133319763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.