Evidence map›Paper›PMID 33590269›Full record

ReviewCellular and molecular life sciences : CMLS2021

Approaches to characterize the transcriptional trajectory of human myogenesis.

HoTae Lim, In Young Choi, Sang-Hwan Hyun, Hyesoo Kim, Gabsang Lee

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

HoTae LimLaboratory of Veterinary Embryology and Biotechnology (VETEMBIO), College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.
In Young ChoiSchool of Medicine, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.
Sang-Hwan HyunLaboratory of Veterinary Embryology and Biotechnology (VETEMBIO), College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Hyesoo KimSchool of Medicine, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.
Gabsang LeeSchool of Medicine, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA. glee48@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Interrogating functional and molecular properties of PAX7+ putative skeletal muscle stem/progenitor cells derived from human iPSCs of healthy donors and Duchenne muscular dystrophy patientsR01AR070751 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI LEE, GABSANG · 2017 to 2021
$1.8M
Cell extrinsic factors' roles on direct conversion to human induced neural crestR01NS093213 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LEE, GABSANG · 2015 to 2019
$1.8M
Maryland Stem Cell Research Fund 2017-MSCRFD-3941Muscular Dystrophy Association 381465National Institute of Neurological Disorders and Stroke (US) R01NS093213NIAMS NIH HHS R01 AR070751NIAMS NIH HHS R01AR070751NINDS NIH HHS R01 NS093213
6 · The paper itself

Abstract

Human pluripotent stem cells (hPSCs) have attracted considerable interest in understanding the cellular fate determination processes and modeling a number of intractable diseases. In vitro generation of skeletal muscle tissues using hPSCs provides an essential model to identify the molecular functions and gene regulatory networks controlling the differentiation of skeletal muscle progenitor cells. Such a genetic roadmap is not only beneficial to understanding human myogenesis but also to decipher the molecular pathology of many skeletal muscle diseases. The combination of established human in vitro myogenesis protocols and newly developed molecular profiling techniques offers extensive insight into the molecular signatures for the development of normal and disease human skeletal muscle tissues. In this review, we provide a comprehensive overview of the current progress of in vitro skeletal muscle generation from hPSCs and relevant examples of the transcriptional landscape and disease-related transcriptional aberrations involving signaling pathways during the development of skeletal muscle cells.

Indexed as

Cell DifferentiationEmbryonic DevelopmentGene Regulatory NetworksHumansMuscle DevelopmentMuscle, SkeletalPluripotent Stem CellsSignal TransductionMyogenesisPluripotent stem cellSkeletal muscle

Identifiers

PMID33590269
PMCPMC11072395
OpenAlexW3132769683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.