ArticleNature2021
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 788 papers.
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788citing papers in PubMed
69.0field-weighted citation impact, top 1% of its field
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Who cites it
788 citing papers in PubMed, 1,171 citations in OpenAlex.
- Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.Genes & diseases · 2027Review
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- Site-specific metabolic and hypoxia-associated profiles in metastatic melanoma.Journal for immunotherapy of cancer · 2026Article
- Lactate Signal: Modulator of Cellular Energy Production and Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells.Signal transduction and targeted therapy · 2026Article
- Systemic health impact of cancer-associated extracellular vesicles and particles.Nature reviews. Cancer · 2026Review
- Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation.Oncology letters · 2026Article
- Tumor microenvironment-mediated resistance to immune checkpoint inhibitors in non-small cell lung cancer: Mechanisms, combination strategies and clinical perspectives (Review).Molecular and clinical oncology · 2026Review
- Immunomodulatory Function of Soluble Dietary Fiber: Toward Application for Prevention and Treatment of Food Allergies.Current allergy and asthma reports · 2026Review
- Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design.Molecular cancer · 2026Review
- Functional Heterogeneity ofMicroorganisms · 2026Article
- FABP4/5-Mediated Lipid Reprogramming Is Associated with Immunosuppressive T Cell Crosstalk in Cervical Cancer After Chemoradiotherapy.Biomedicines · 2026Article
- Spatially resolved lactate-glycolysis transcriptional programs are associated with neutrophil-enriched immune remodeling in lung adenocarcinoma.Medical oncology (Northwood, London, England) · 2026Article
- CPS1: a multipurpose mitochondrial enzyme, bile protein, acute liver injury biomarker, and cytokine.Gut · 2026Review
- Lactylation-related prognostic signature characterized in pancreatic ductal adenocarcinoma through public scRNA-seq dataset and machine learning algorithms: the TOP2A-H3K18la-NQO1 axis orchestrates malignant progression.British journal of cancer · 2026Article
- From immune checkpoint blockade to metabolic ecosystem intervention: A new perspective on ammonia-mediated remodelling of tumour immunity.Clinical and translational medicine · 2026Article
- Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Review
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Single-cell and spatial transcriptomics reveal lactate-active epithelial-immune cell crosstalk that reprograms the immune microenvironment in colorectal cancer.Translational oncology · 2026Article
728 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
McLane J WatsonDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Paolo D A VignaliDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Steven J MullettHealth Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA, USA.
Abigail E Overacre-DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Ronal M PeraltaDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Stephanie GrebinoskiDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3562-3190
Ashley V MenkTumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Natalie L RittenhouseDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Kristin DePeauxDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-8460-727X
Ryan D WhetstoneDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2771-5992
Timothy W HandDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Amanda C PoholekDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Brett M MorrisonDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeffrey D RothsteinDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2001-8470
Stacy G WendellHealth Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA, USA.
Greg M DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. gdelgoffe@pitt.edu.ORCID http://orcid.org/0000-0002-2957-8135
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USJohns Hopkins University · USUPMC Hillman Cancer Center · US
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0MWILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8MTherapuetic Immune Targeting of EphA2 Expressed by Melanoma & Its Tumor-AssociateP50CA121973 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIRKWOOD, JOHN MUNN · 2008 to 2018
$22.9MTraining in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2MAutoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6MOligodendroglial Dysfunction in C9orf72 ALS and FTDR01NS099320 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MORRISON, BRETT M., ROTHSTEIN, JEFFREY D · 2017 to 2021
$3.0MParameters that Underlie Treg Insufficiency in Autoimmune DiabetesR01DK089125 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIGNALI, DARIO AA · 2011 to 2020
$2.9MExploring and exploiting metabolic plasticity in regulatory T cellsDP2AI136598 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2017 to 2017
$2.3MInterleukin-35 and the tumor microenvironmentR01CA203689 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIGNALI, DARIO AA · 2016 to 2020
$1.9MRole of Monocarboxylate Transporters in the Recovery from Peripheral Nerve InjuryR01NS086818 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MORRISON, BRETT M. · 2015 to 2019
$1.8MBringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594kNCI NIH HHS F30 CA247034NCI NIH HHS F31 CA247129NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS P50 CA121973NCI NIH HHS R01 CA203689NCI NIH HHS T32 CA082084NIAID NIH HHS DP2 AI136598NIAID NIH HHS F31 AI147638NIAID NIH HHS F31 AI149971NIAID NIH HHS P01 AI108545NIAID NIH HHS R21 AI135367NIAID NIH HHS T32 AI089443NIDDK NIH HHS R01 DK089125NIH HHS S10 OD020007NIH HHS S10 OD023402NINDS NIH HHS R01 NS086818NINDS NIH HHS R01 NS099320
Abstract
Regulatory T (T
Indexed as
AnimalsCell Line, TumorCell ProliferationFemaleGlucoseHumansLactic AcidLymphocytes, Tumor-InfiltratingMaleMiceNeoplasmsSuppressor Factors, ImmunologicT-Lymphocytes, RegulatoryGlucoseLactic AcidSuppressor Factors, Immunologic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.