ArticleThe ISME journal2021
Interspecies bacterial competition regulates community assembly in the C. elegans intestine.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Seasonal Variation in the Assembly Mechanisms and Co-Occurrence Patterns of Bacterial Communities in Water and Sediments of Reservoirs in Arid and Semi-Arid Regions.Microorganisms · 2026Article
- Quartet: Disentangling positive and negative components of microbial interactions.PLoS computational biology · 2026Article
- From Gut to Gain: The Microbiome's Contribution to Broiler Health and Productivity.Veterinary sciences · 2026Review
- Functional and ecological drivers of bacterial interactions in glacier-fed stream biofilms.mSystems · 2026Article
- The island biology of the host microbiome.Trends in microbiology · 2026Review
- Unique Transcriptional Responses by the Sea Anemone Nematostella vectensis to Individual Bacteria: Roles for Bacterial Species, Secreted Products and the Microbiome.Molecular ecology · 2026Article
- Cluster dispersal shapes microbial diversity during community assembly.PLoS computational biology · 2026Article
- Polystyrene-degrading bacteria modulate host stress and toxicity responses to microplastic exposure in Caenorhabditis elegans.The ISME journal · 2026Article
- Host and microbial factors influence bacterial colonization of the honey bee gut.The ISME journal · 2026Article
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- Immunomodulatory effects of nematode-microbiota interactions in cancer therapy.Frontiers in immunology · 2026Review
- Transitive interactions among rhizobia determine their symbiotic fitness.ISME communications · 2026Article
- Mechanism ofFrontiers in microbiology · 2026Article
- Drivers of diversity within and between microbial communities during stochastic assembly.Journal of the Royal Society, Interface · 2025Article
- Gut Bacteria Strategies ofMicroorganisms · 2025Article
- Multispecies Coexistence Emerges From Pairwise Exclusions in Communities With Competitive Hierarchy.Ecology letters · 2025Article
- Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?Ecology and evolution · 2025Review
- Systematic pairwise co-cultures uncover predominant negative interactions among human gut bacteria.Microbiome · 2025Article
- Competition and cooperation: The plasticity of bacterial interactions across environments.PLoS computational biology · 2025Article
- Dynamic fluid layer around immotile yeast colonies mediates the spread of bacteria.Biophysical journal · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From insects to mammals, a large variety of animals hold in their intestines complex bacterial communities that play an important role in health and disease. To further our understanding of how intestinal bacterial communities assemble and function, we study the C. elegans microbiota with a bottom-up approach by feeding this nematode with bacterial monocultures as well as mixtures of two to eight bacterial species. We find that bacteria colonizing well in monoculture do not always do well in co-cultures due to interspecies bacterial interactions. Moreover, as community diversity increases, the ability to colonize the worm gut in monoculture becomes less important than interspecies interactions for determining community assembly. To explore the role of host-microbe adaptation, we compare bacteria isolated from C. elegans intestines and non-native isolates, and we find that the success of colonization is determined more by a species' taxonomy than by the isolation source. Lastly, by comparing the assembled microbiotas in two C. elegans mutants, we find that innate immunity via the p38 MAPK pathway decreases bacterial abundances yet has little influence on microbiota composition. These results highlight that bacterial interspecies interactions, more so than host-microbe adaptation or gut environmental filtering, play a dominant role in the assembly of the C. elegans microbiota.
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