Observational studyScientific reports2021
Predictors of brain infarction in adult patients on extracorporeal membrane oxygenation: an observational cohort study.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Risk factors for neurological complications in adult ECMO patients: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Polymicrobial Multidrug-Resistant Infection and Fatal Bowel Ischemic Perforation After Urgent Heart Transplantation in a VA-ECMO-Bridged Recipient: A Case Report.Infection and drug resistance · 2026Article
- Incidence and impact of intracranial complications in patients undergoing extracorporeal membrane oxygenation treatment.Brain & spine · 2026Article
- Predictors of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) failure: analysis of comorbidities and complications - a 10-year experience.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2025Article
- Risk of acute ischemic stroke with early versus late initiation of mechanical circulatory support in hospitalizations with acute myocardial infarction complicated by cardiogenic shock: a propensity-matched analysis.BMC cardiovascular disorders · 2025Article
- Performance Comparison of Centered and Tilted Blunt and Lighthouse Tip Cannulae for Drainage in Extracorporeal Life Support.Cardiovascular engineering and technology · 2025Article
- Endovascular Thrombectomy for Large Vessel Occlusion in a Patient on Venoarterial Extracorporeal Membrane Oxygenation: A Case Report.NMC case report journal · 2025Article
- Acute Ischemic Stroke during Extracorporeal Membrane Oxygenation (ECMO): A Narrative Review of the Literature.Journal of clinical medicine · 2024Review
- The neurobiology of SARS-CoV-2 infection.Nature reviews. Neuroscience · 2024Review
- Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula.Biomechanics and modeling in mechanobiology · 2023Article
- Neuromonitoring During ECMO Support in Children.Neurocritical care · 2023Review
- Predictors of intracranial hemorrhage in neonatal patients on extracorporeal membrane oxygenation.Scientific reports · 2023Observational
- Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Numerical and experimental investigation of a lighthouse tip drainage cannula used in extracorporeal membrane oxygenation.Artificial organs · 2023Article
- Incidence and predictors of brain infarction in neonatal patients on extracorporeal membrane oxygenation: an observational cohort study.Scientific reports · 2022Observational
- Prior Antiplatelet Therapy and Stroke Risk in Critically Ill Patients Undergoing Extracorporeal Membrane Oxygenation.International journal of environmental research and public health · 2021Article
- Overview of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support for the Management of Cardiogenic Shock.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-hemorrhagic brain infarction (BI) is a recognized complication in adults treated with extracorporeal membrane oxygenation (ECMO) and associated with increased mortality. However, predictors of BI in these patients are poorly understood. The aim of this study was to identify predictors of BI in ECMO-treated adult patients. We conducted an observational cohort study of all adult patients treated with venovenous or venoarterial (VA) ECMO at our center between 2010 and 2018. The primary endpoint was a computed tomography (CT) verified BI. Logistic regression models were employed to identify BI predictors. In total, 275 patients were included, of whom 41 (15%) developed a BI. Pre-ECMO Simplified Acute Physiology Score III, pre-ECMO cardiac arrest, VA ECMO and conversion between ECMO modes were identified as predictors of BI. In the multivariable analysis, VA ECMO demonstrated independent risk association. VA ECMO also remained the independent BI predictor in a sub-group analysis excluding patients who did not undergo a head CT scan during ECMO treatment. The incidence of BI in adult ECMO patients may be higher than previously believed and is independently associated with VA ECMO mode. Larger prospective trials are warranted to validate these findings and ascertain their clinical significance.
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