Evidence map›Paper›PMID 33589662›Full record

ArticleScientific reports2021

Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation.

Tiffany S Ko, Constantine D Mavroudis, Ryan W Morgan, Wesley B Baker, Alexandra M Marquez, Timothy W Boorady, Mahima Devarajan, Yuxi Lin, Anna L Roberts, William P Landis and 8 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Tiffany S KoDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Constantine D MavroudisDivision of Cardiovascular Surgery, Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Ryan W MorganDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Wesley B BakerDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Alexandra M MarquezDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Timothy W BooradyDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Mahima DevarajanDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Yuxi LinDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Anna L RobertsDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
William P LandisDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Kobina Mensah-BrownDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Robert A BergDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Robert M SuttonDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA, 19104, USA.
Daniel J LichtDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Wensheng GuoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19104, USA.
Todd J KilbaughDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. kilbaugh@chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USHospital of the University of Pennsylvania · US

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Improving Pediatric Cardiac Arrest Survival and Neurologic OutcomeR01HL141386 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI KILBAUGH, TODD JUSTEN · 2019 to 2023
$4.4M
Pulmonary Hypertension-Associated Pediatric Cardiac ArrestK23HL148541 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MORGAN, RYAN WILLIAM · 2020 to 2024
$791k
Pulmonary Vasodilator Therapy During Resuscitation from Cardiac ArrestR21HD089132 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN · 2017 to 2018
$462k
Functional Diffuse Optical Measurements of Psychomotor Function in Neonates with Hypoplastic Left Heart Syndrome (HLHS)F31HD085731 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI KO, TIFFANY S · 2016 to 2019
$133k
NCATS NIH HHS TL1 TR001880NHLBI NIH HHS K23 HL148541NHLBI NIH HHS R01 HL141386NHLBI NIH HHS T32 HL007915NIBIB NIH HHS P41 EB015893NICHD NIH HHS F31 HD085731NICHD NIH HHS R21 HD089132NIH HHS F31-HD085731NIH HHS K23-HL148541NIH HHS P41-EB015893NIH HHS R01-HL141386NIH HHS R01-NS060653NIH HHS R21-HD089132NIH HHS TL1-TR001880NINDS NIH HHS R01 NS060653
6 · The paper itself

Abstract

Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess the feasibility of quantitative, non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) neuromonitoring during cardiopulmonary resuscitation (CPR), and its predictive utility for return of spontaneous circulation (ROSC) in an established pediatric swine model of cardiac arrest. Cerebral tissue optical properties, oxy- and deoxy-hemoglobin concentration ([HbO

Indexed as

Return of Spontaneous CirculationAnimalsBiomarkersBrainCardiopulmonary ResuscitationCerebrovascular CirculationClinical Decision-MakingDisease ManagementDisease Models, AnimalHeart ArrestHemodynamicsMaleSpectrum AnalysisSwineTranslational Research, BiomedicalBiomarkers

Identifiers

PMID33589662
PMCPMC7884428
OpenAlexW3131325911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.