ArticleNature communications2021
Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Pooled it
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Random auditory stimulation during sleep disturbs traveling slow waves and declarative memory.iScience · 2026Article
- Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humans.bioRxiv : the preprint server for biology · 2026Article
- Wave turbulence and cortical dynamics.Frontiers in computational neuroscience · 2026Article
- Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.bioRxiv : the preprint server for biology · 2025Article
- Article
- Spatiotemporal dynamics of sleep spindles form spiral waves that predict overnight memory consolidation and age-related memory decline.Communications biology · 2025Article
- Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex.Journal of neurophysiology · 2025Article
- Differential expression of spatiotemporal sleep spindle clusters in aging.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Membrane potential states gate synaptic consolidation in human neocortical tissue.Nature communications · 2024Article
- Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.PLoS biology · 2024Article
- Thalamic epileptic spikes disrupt sleep spindles in patients with epileptic encephalopathy.Brain : a journal of neurology · 2024Article
- Article
- Neural oscillations and memory: unraveling the mechanisms of anesthesia-induced amnesia.Frontiers in neuroscience · 2024Review
- Sleep, oscillations, and epilepsy.Epilepsia · 2023Article
- Beta traveling waves in monkey frontal and parietal areas encode recent reward history.Nature communications · 2023Article
- How coupled slow oscillations, spindles and ripples coordinate neuronal processing and communication during human sleep.Nature neuroscience · 2023Article
- Perceptual echoes as travelling waves may arise from two discrete neuronal sources.NeuroImage · 2023Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Sleep spindles facilitate memory consolidation in the cortex during mammalian non-rapid eye movement sleep. In rodents, phase-locked firing during spindles may facilitate spike-timing-dependent plasticity by grouping pre-then-post-synaptic cell firing within ~25 ms. Currently, microphysiological evidence in humans for conditions conducive for spike-timing-dependent plasticity during spindles is absent. Here, we analyze field potentials and unit firing from middle/upper layers during spindles from 10 × 10 microelectrode arrays at 400 μm pitch in humans. We report strong tonic and phase-locked increases in firing and co-firing within 25 ms during spindles, especially those co-occurring with down-to-upstate transitions. Co-firing, spindle co-occurrence, and spindle coherence are greatest within ~2 mm, and high co-firing of units on different contacts depends on high spindle coherence between those contacts. Spindles propagate at ~0.28 m/s in distinct patterns, with correlated cell co-firing sequences. Spindles hence organize spatiotemporal patterns of neuronal co-firing in ways that may provide pre-conditions for plasticity during non-rapid eye movement sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.