ArticleNPJ Parkinson's disease2021
"Hot cross bun" is a potential imaging marker for the severity of cerebellar ataxia in MSA-C.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Repetitive transcranial magnetic stimulation improves cognition, depression, and walking ability in patients with Parkinson's disease: a meta-analysis.BMC neurology · 2024Pooled it
- Integrated quantitative susceptibility mapping and radiomics for multiple system atrophy subtypes classification.Neuroradiology · 2026Article
- Development of a radiomics-based model for diagnosis of multiple system atrophy using multimodal MRI.Frontiers in neurology · 2025Article
- Imaging Markers of Multiple System Atrophy and Their Association With Disease Severity: A Cross-Sectional Study.Cureus · 2024Article
- "Hot Cross Bun" Sign in a Patient with Glutamic Acid Decarboxylase 65-KDa Isoform Associated Cerebellar Ataxia: Case Report and Review of the Literature.Cerebellum (London, England) · 2024Review
- Antisaccades in Spinocerebellar Ataxia Type 17 With Middle Cerebellar Peduncle Hyperintensities Without Hot-Cross-Bun Sign.Journal of clinical neurology (Seoul, Korea) · 2024Article
- MRl and MRS hints for the differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia type II.Heliyon · 2024Article
- Identification of Parkinson's disease and multiple system atrophy using multimodal PET/MRI radiomics.European radiology · 2024Article
- Identifying New Subtypes of Multiple System Atrophy Using Cluster Analysis.Journal of Parkinson's disease · 2024Article
- Simple biomarkers to distinguish Parkinson's disease from its mimics in clinical practice: a comprehensive review and future directions.Frontiers in neurology · 2024Review
- QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis.Aging and disease · 2023Article
- Heterozygous Nonsense Variants in the Ferritin Heavy Chain GenemedRxiv : the preprint server for health sciences · 2023Article
- Efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease: A systematic review and meta-analysis of randomised controlled trials.EClinicalMedicine · 2022Article
- Radiological hints for differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia.Scientific reports · 2022Article
- Erythrocytes Are an Independent Protective Factor for Vascular Cognitive Impairment in Patients With Severe White Matter Hyperintensities.Frontiers in aging neuroscience · 2022Article
- Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- FTD-PSP is an Unusual Clinical Phenotype in A Frontotemporal Dementia Patient with A Novel Progranulin Mutation.Aging and disease · 2021Article
- The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease.Annals of clinical and translational neurology · 2021Review
- Divergent Connectivity Changes in Gray Matter Structural Covariance Networks in Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
To evaluate the correlation between "hot cross bun" sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collected and comparison was performed between MSA-C and MSA-P cases. Spearman test was used to evaluate the correlation between HCBs and other variables. Curve estimate and general linear regression was performed to evaluate the relationship between HCBs and the Scale for Assessment and Rating of Ataxia (SARA). Unified Multiple System Atrophy Rating Scale (UMSARS) IV was used to assess the severity of disease. Multinomial ordered logistic regression was used to confirm the increased likelihood of disability for the disease. Eighty-one MSA with HCBs comprising of 50 MSA-C and 31 MSA-P were recruited. We demonstrated that the severity of HCBs showed a positive linear correlation with SARA scores in MSA-C. Multinomial ordered logistic regression test revealed that the increase in the HCBs grade may be associated with an increased likelihood of disability for the disease severity in MSA, especially in those with cerebellar ataxia subtype. We demonstrated that HCBs is a potential imaging marker for the severity of cerebellar ataxia. The increase in the HCBs grade may be associated with an increased likelihood of disability in MSA-C, but not MSA-P cases, suggesting that it may be a useful imaging indicator for disease progression in Chinese patients with MSA-C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.