Evidence map›Paper›PMID 33589606›Full record

ArticleCell death & disease2021

Loss of the orphan nuclear receptor NR2F6 enhances CD8

Bojana Jakic, William J Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Loss of NR2F6 Protects from Salmonella Typhimurium Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  12. CTLs: Killers of intracellular bacteria.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Article
  14. Bacterial Infection withBio-protocol · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Bojana JakicTranslational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-2339-5928
William J OlsonTranslational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Kerstin SiegmundTranslational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Victoria KlepschTranslational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-4146-4664
Janine KimpelInstitute of Virology, Medical University of Innsbruck, Innsbruck, Austria.
Verena LabiInstitute of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-7538-1520
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Gottfried BaierTranslational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-2085-8325
Natascha Hermann-KleiterTranslational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria. natascha.kleiter@i-med.ac.at.ORCID 0000-0003-4389-9813
Innsbruck Medical University · ATTechnical University of Munich · DEUppsala University · SE

Funding

Austrian Science Fund FWF P 28694
6 · The paper itself

Abstract

Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into either short-lived effector cells (SLECs, CD127

Indexed as

AnimalsCD8-Positive T-LymphocytesFemaleInterferon-gammaMaleMiceMice, Inbred C57BLOrphan Nuclear ReceptorsRepressor ProteinsInterferon-gammaNr2f6 protein, mouseOrphan Nuclear ReceptorsRepressor Proteins

Identifiers

PMID33589606
PMCPMC7884426
OpenAlexW3129753822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.