ArticleNature communications2021
Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.American journal of human genetics · 2022Pooled it
- Ancient Somatosensory Circuit Architectures Employ Flexible Molecular Strategies.bioRxiv : the preprint server for biology · 2026Article
- A who's who of cell types in skeletal muscle.Communications biology · 2026Review
- Artemin/GFRA3 axis and TRP channels: molecular insights from a feline model of osteoarthritis.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Review
- A Reference Atlas of the Human Dorsal Root Ganglion.bioRxiv : the preprint server for biology · 2025Article
- Sensory Feedback and the Dynamic Control of Movement.Annual review of neuroscience · 2025Review
- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
- Temporal refinement of Dach1 expression contributes to the development of somatosensory neurons.The EMBO journal · 2025Article
- Article
- Focal Adhesion Kinase Inhibition Ameliorates Burn Injury-Induced Chronic Pain in Rats.Molecular neurobiology · 2025Article
- Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration.Nature communications · 2025Article
- Postural Differences in Speaking Versus Non-Speaking Children with Autism Spectrum Disorder.Children (Basel, Switzerland) · 2025Article
- Sensory feedback for gait in transtibial amputees: a narrative review of technologies and clinical outcomes.Frontiers in bioengineering and biotechnology · 2025Review
- Molecular and developmental insights into proprioceptive identity in the mesencephalic trigeminal nucleus neurons.Frontiers in cellular neuroscience · 2025Review
- Article
- GPR88 promotes neurite outgrowth of sensory neurons via activation of GFrontiers in pharmacology · 2025Article
- Sensory-spinal neuron co-culture platform enables analysis of sensory-driven spinal activation.Frontiers in neuroscience · 2025Article
- Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia.Science advances · 2024Article
- Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.