ArticleOpen heart2021
Prognostic comparison of atrial and ventricular functional mitral regurgitation.
Article in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Clinical value of RT-3DE in evaluating mitral valve configuration and the occurrence of VFMR in patients with ischemic cardiomyopathy: a clinical investigation.BMC cardiovascular disorders · 2026Observational
- Atrial Secondary Mitral Regurgitation: Pathophysiology, Diagnosis, and Surgical Implications.Medicina (Kaunas, Lithuania) · 2026Review
- Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair.Journal of cardiovascular development and disease · 2025Review
- Evolving Perspectives in Surgery for Mitral Regurgitation: Why Sex Matters.Journal of the American Heart Association · 2025Review
- Outcomes of Mitral Valve Surgery for Atrial Functional Mitral Regurgitation vs Ventricular Functional Mitral Regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- A Case of Immediate Reduction of Severe Mitral Regurgitation After the Ablation of Atrial Flutter.Cureus · 2025Article
- Burden of Mitral Regurgitation in Spain from 2016-2021: An Analysis by Aetiology and Sex.Journal of clinical medicine · 2024Article
- Transcatheter Mitral Valve Intervention: Current and Future Role of Multimodality Imaging for Device Selection and Periprocedural Guidance.Medicina (Kaunas, Lithuania) · 2024Review
- Outcomes of transcatheter edge-to-edge repair for atrial functional mitral regurgitation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Functional Mitral and Tricuspid Regurgitation across the Whole Spectrum of Left Ventricular Ejection Fraction: Recognizing the Elephant in the Room of Heart Failure.Journal of clinical medicine · 2023Review
- Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes.Echo research and practice · 2023Article
- Atrial functional mitral regurgitation: prevalence, characteristics and outcomes from the National Echo Database of Australia.Open heart · 2023Article
- Aetiology of chronic heart failure in patients from a super-aged society: the KUNIUMI registry chronic cohort.ESC heart failure · 2023Observational
- Atrial Mitral and Tricuspid Regurgitation: Sex Matters. A Call for Action to Unravel the Differences Between Women and Men.Frontiers in cardiovascular medicine · 2022Review
- The atrial secondary tricuspid regurgitation is associated to more favorable outcome than the ventricular phenotype.Frontiers in cardiovascular medicine · 2022Article
- Impact of secondary mitral regurgitation on survival in atrial and ventricular dysfunction.PloS one · 2022Article
- Secondary mitral regurgitation repair techniques and outcomes: Subannular repair techniques in secondary mitral regurgitation type IIIb.JTCVS techniques · 2021Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAtrial functional mitral regurgitation (A-FMR) has been suggested as a new aetiology of functional MR (MR); however, its prognosis and prognostic predictors are not fully elucidated. Aim of this study was to investigate the prognosis and prognostic predictors of A-FMR in comparison with ventricular functional MR (V-FMR).
methodsThree hundred and seventy-eight consecutive patients with moderate-to-severe or severe functional MR were studied. Functional MR was classified into V-FMR (N=288) and A-FMR (N=90) depending on the alterations of left ventricle (LV) or left atrium (LA) along with clinical context and diagnosis of ischaemic heart disease or cardiomyopathy.
resultsDuring a median follow-up of 4.1 (2.0-6.7) years, all-cause mortality, cardiovascular mortality and heart failure (HF) hospitalisation occurred in 98 (26%), 81 (21%) and 177 (47%) patients, respectively, and rates of these events and the composite end point of all-cause mortality and HF hospitalisation were consistently higher in V-FMR than A-FMR (unadjusted HR 1.762 (95% CI 1.250 to 2.438), p<0.001; adjusted HR 1.654 (95% CI 1.027 to 2.664), p=0.038, for the composite end point). Further analysis showed different prognostic predictors between V-FMR and A-FMR; while age and LA volume index were independent prognostic predictors of both V-FMR and A-FMR, systolic blood pressure and B-type natriuretic peptide were also those of V-FMR, and estimated glomerular filtration rate, LV end-systolic dimension and tricuspid regurgitation were also those of A-FMR.
conclusionsThe prognosis of V-FMR was significantly worse than that of A-FMR, and prognostic predictors were different between V-FMR and A-FMR. Our study suggests the importance of discriminating A-FMR and V-FMR, and that different treatment strategies may be considered for each aetiology.
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