ArticleCancer discovery2021
PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability.
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Article in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
3.1field-weighted citation impact, top 6% of its field
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Who cites it
42 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Coordinated Immune Activation Following KRAS Inhibition in Syngeneic Models Reveals Molecular Pathways that Potentiate and Limit Antitumor Immunity.Cancer immunology research · 2026Article
- Hypoxic CAF studies unveil PTHrP‑vitamin D‑RAS axis as pivotal in the CAF.Oncology reports · 2026Article
- Parathyroid hormone-related protein is a therapeutic target in idiopathic pulmonary fibrosis.Signal transduction and targeted therapy · 2026Article
- Signatures of Pancreatic Ductal Adenocarcinoma Uncovered by Integrative Multi-Omics Analysis.Cancers · 2026Article
- Ablation of cancer cell secreted neuropeptide PTHLH/PTHrP provokes anti-tumor immunity in murine tongue squamous cell carcinoma.Scientific reports · 2026Article
- Targeting of HIF2-driven cachexia in kidney cancer.Nature medicine · 2026Article
- Downregulation of the CCK-B Receptor in Pancreatic Stellate Cells Blocks Molecular Proliferative Pathways and Increases Apoptosis to Decrease Pancreatic Cancer Growth In Vitro.International journal of molecular sciences · 2025Article
- ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment.bioRxiv : the preprint server for biology · 2025Article
- Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma.Nature genetics · 2025Article
- SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.Nature cancer · 2025Article
- [Overexpression of parathyroid hormone-like hormone facilitates hepatocellular carcinoma progression and correlates with adverse outcomes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors.bioRxiv : the preprint server for biology · 2025Article
- Acute kidney injury: pathogenesis and therapeutic interventions.Molecular biomedicine · 2025Review
- Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adiposebioRxiv : the preprint server for biology · 2025Article
- Experimental models of pancreas cancer: what has been the impact for precision medicine?The Journal of clinical investigation · 2025Review
- Bioinformatics Screening of Tumor-Derived Neuropeptides Mediating Neuroimmune Axis of Head and Neck Cancer.Cancers · 2025Article
- Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer.bioRxiv : the preprint server for biology · 2025Article
- Mitochondrial CaCell reports · 2025Article
- Refractory hypercalcemia caused by parathyroid-hormone-related peptide secretion from a metastatic pancreatic neuroendocrine tumor: a case report.Journal of medical case reports · 2025Article
Corrections and comments
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Authors and funding
23 authors at 6 institutions in 3 countries.
Jason R PitarresiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0001-9549-4768
Robert J NorgardDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Anna M ChiarellaHerbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0003-1224-9324
Kensuke SuzukiHerbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Basil BakirDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Varun SahuHerbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Jinyang LiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0001-8125-6603
Jun ZhaoSheikh Ahmed Center for Pancreatic Cancer Research and the Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Benoît MarchandDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0001-9302-6688
Maximilian D WengynDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Antony HsiehDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Il-Kyu KimDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Amy ZhangDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.
Karine SellinDivision of Endocrinology and Metabolism, Department of Medicine, McGill University and McGill University Health Centre, Montréal, Quebec, Canada.
Vivian LeeDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.
Shigetsugu TakanoDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-6495-0422
Yoji MiyaharaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-5636-2607
Masayuki OhtsukaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Anirban MaitraSheikh Ahmed Center for Pancreatic Cancer Research and the Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Faiyaz NottaDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.
Richard KremerDivision of Endocrinology and Metabolism, Department of Medicine, McGill University and McGill University Health Centre, Montréal, Quebec, Canada.ORCID 0000-0002-7053-2139
Ben Z StangerDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0003-0410-4037
Anil K RustgiHerbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York. akr2164@cumc.columbia.edu.
University of Pennsylvania · USColumbia University Irving Medical Center · USChiba University · JPMcGill University Health Centre · CAThe University of Texas MD Anderson Cancer Center · USUniversity of Toronto · CA
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MThe Prrx-1 transcription factor in pancreatic ductal biologyR01DK060694 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CHANDWANI, ROHIT, RUSTGI, ANIL K · 2002 to 2025
$8.3MMolecular Determinants and Therapeutic Consequences of Immune Heterogeneity in CancerR01CA229803 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STANGER, BEN Z · 2018 to 2022
$3.7MDissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancerK99CA252153 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PITARRESI, JASON R. · 2021 to 2022
$275kThe role of p120ctn in PDAC epithelial-to-mesenchymal transition and metastasisF32CA221094 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PITARRESI, JASON R. · 2017 to 2018
$115kCIHR MOP142287NCI NIH HHS F32 CA221094NCI NIH HHS K99 CA252153NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA229803NIDDK NIH HHS R01 DK060694
Abstract
Pancreatic cancer metastasis is a leading cause of cancer-related deaths, yet very little is understood regarding the underlying biology. As a result, targeted therapies to inhibit metastasis are lacking. Here, we report that the parathyroid hormone-related protein (PTHrP encoded by
Indexed as
AnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMiceMice, Inbred C57BLMice, Inbred StrainsNeoplasm MetastasisPancreatic NeoplasmsParathyroid Hormone-Related ProteinParathyroid Hormone-Related ProteinPTHLH protein, human
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