ArticleDental materials : official publication of the Academy of Dental Materials2021
Benchtop plasma treatment of titanium surfaces enhances cell response.
Article in Dental materials : official publication of the Academy of Dental Materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical evaluation of cold plasma surface activation using different plasma systems on early implant stability: a randomized controlled within-patient trial.BMC oral health · 2026Trial
- A Microscopic Heterogeneous LiBOAdvanced materials (Deerfield Beach, Fla.) · 2026Article
- Cold atmospheric plasma for implant surface decontamination and osseointegration: a scoping review with implications for peri-implantitis management.BMC oral health · 2026Article
- Unveiling the characteristics and surface modification of titanium, zirconia, and polyetheretherketone dental implants.Journal of dental sciences · 2025Review
- Impact of Plasma Surface Treatment on Implant Stability and Early Osseointegration: A Retrospective Cohort Study.Materials (Basel, Switzerland) · 2025Article
- Diagnostic Value of lncRNA XIST in Saliva for Early Peri-Implantitis.Oral health & preventive dentistry · 2024Article
- Bone-to-Implant Contact in Implants with Plasma-Treated Nanostructured Calcium-Incorporated Surface (XPEEDActive) Compared to Non-Plasma-Treated Implants (XPEED): A Human Histologic Study at 4 Weeks.Materials (Basel, Switzerland) · 2024Article
- Strategies for Improving Impaired Osseointegration in Compromised Animal Models.Journal of dental research · 2024Review
- Different Methods to Modify the Hydrophilicity of Titanium Implants with Biomimetic Surface Topography to Induce Variable Responses in Bone Marrow Stromal Cells.Biomimetics (Basel, Switzerland) · 2024Article
- Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction-based process and osteogenic in vivo responses.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Gas Plasma Treatment Improves Titanium Dental Implant Osseointegration-A Preclinical In Vivo Experimental Study.Bioengineering (Basel, Switzerland) · 2023Article
- Influence of Plasma Treatment on Surface Characteristics of Aluminum Alloy Sheets and Bonding Performance of Glass Fiber-Reinforced Thermoplastic/Al Composites.Materials (Basel, Switzerland) · 2023Article
- Improvement of osseointegration efficacy of titanium implant through plasma surface treatment.Biomedical engineering letters · 2022Article
- Article
- Hydrophilic implants generated using a low-cost dielectric barrier discharge plasma device at the time of placement exhibit increased osseointegration in an animal pre-clinical study: An effect that is sex-dependent.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Influence of cold atmospheric plasma on dental implant materials - an in vitro analysis.Clinical oral investigations · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveModifications to implant surface properties, including topography, chemistry, and wettability, alter immune response, osteoblast differentiation of bone marrow stromal cells (MSCs), and implant integration in vivo. Dielectric barrier discharge (DBD) plasma treatment has been used to sterilize surfaces and remove adsorbed carbon, improving wettability. However, unless it is used immediately prior to placement, ambient atmospheric hydrocarbons rapidly adhere to the surface, thereby reducing its hydrophilicity. Moreover, this method is not practical in many clinical settings. The aim of this study was to evaluate the effectiveness of an on-site benchtop modification technique for implants at time of placement, consisting of a DBD plasma that is used to sterilize implants that are pre-packaged in a vacuum. Effects of the plasma-treatment on implant surface properties and cellular response of MSCs and osteoblasts were assessed in vitro.
methodsTitanium-aluminum-vanadium implant surfaces were grit-blasted (GB) or grit-blasted and acid-etched (AE), and packaged under vacuum. AE surfaces were also plasma-treated using the benchtop device (GB + AE) and then removed from the vacuum. GB surface morphology was altered with AE but AE microroughness was not changed with the plasma-treatment. Plasma-treatment increased the surface wettability, but did not alter surface atomic concentrations of titanium, oxygen, or carbon.
resultsMSCs and osteoblast-like cells (MG63 s) produced increased concentrations of osteocalcin, osteopontin, and osteoprotegerin after plasma-treatment of AE surfaces compared to non-plasma-treated AE surfaces; production of IL6 was reduced and IL10 was. Aging GB + AE surfaces for 7 days after plasma-treatment but still in the vacuum environment reduced the effectiveness of plasma on cellular response. SIGNIFICANCE: Overall, these data suggest that application of benchtop plasma at the time of implant placement can alter the surface free energy of an implant surface without modifying surface chemical composition and enhance the differentiation and activity of MSCs and osteoblasts that are in contact with these implant surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.