Evidence map›Paper›PMID 33588992›Full record

ArticleeLife2021

Individual variation in Achilles tendon morphology and geometry changes susceptibility to injury.

Nai-Hao Yin, Paul Fromme, Ian McCarthy, Helen L Birch

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nai-Hao YinResearch Department of Orthopaedics and Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore, United Kingdom.ORCID 0000-0002-6764-9790
Paul FrommeDepartment of Mechanical Engineering, University College London, London, United Kingdom.ORCID 0000-0001-5992-2526
Ian McCarthyPedestrian Accessibility and Movement Environment Laboratory, Department of Civil, Environmental and Geomatic Engineering, University College London, London, United Kingdom.
Helen L BirchResearch Department of Orthopaedics and Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, Stanmore, United Kingdom.ORCID 0000-0002-7966-9967

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unique structure of the Achilles tendon, combining three smaller sub-tendons, enhances movement efficiency by allowing individual control from connected muscles. This requires compliant interfaces between sub-tendons, but compliance decreases with age and may account for increased injury frequency. Current understanding of sub-tendon sliding and its role in the whole Achilles tendon function is limited. Here we show changing the degree of sliding greatly affects the tendon mechanical behaviour. Our in vitro testing discovered distinct sub-tendon mechanical properties in keeping with their mechanical demands. In silico study based on measured properties, subject-specific tendon geometry, and modified sliding capacity demonstrated age-related displacement reduction similar to our in vivo ultrasonography measurements. Peak stress magnitude and distribution within the whole Achilles tendon are affected by individual tendon geometries, the sliding capacity between sub-tendons, and different muscle loading conditions. These results suggest clinical possibilities to identify patients at risk and design personalised rehabilitation protocols.

Indexed as

Achilles TendonAdultAgedAged, 80 and overAge FactorsBiomechanical PhenomenaComputer SimulationFemaleHumansMaleMiddle AgedMovementUltrasonographyAchilles tendoncomputational biologyhumaninjurymechanical propertymedicinesystems biology

Identifiers

PMID33588992
PMCPMC7886322

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.