Evidence map›Paper›PMID 33588948›Full record

ArticleCardio-oncology (London, England)2021

High intensity exercise during breast cancer chemotherapy - effects on long-term myocardial damage and physical capacity - data from the OptiTrain RCT.

Josefin Ansund, Sara Mijwel, Kate A Bolam, Renske Altena, Yvonne Wengström, Eric Rullman, Helene Rundqvist

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06672120 (Exercise in Regional Breast Cancer With Neoadjuvant Anthracycline- Based Chemotherapy and Immunotherapy With Checkpoint-Inhibition), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06672120 narecruitingnot on this mapstarted 2025, after this paper: background citation

Exercise in Regional Breast Cancer With Neoadjuvant Anthracycline- Based Chemotherapy and Immunotherapy With Checkpoint-Inhibition

TypeinterventionalSponsorTechnical University of MunichRan2025 to 2028Enrolled120ConditionsCancer, BreastArmsExercise training
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Exercise for the mitigation of cancer therapy-related cardiac dysfunction in breast cancer patients treated with anthracyclines: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  5. The impact of multimodal high intensity exercise program comparing online and onsite interventions in breast cancer survivors: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Josefin AnsundDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Sara MijwelDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Kate A BolamDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Renske AltenaCancer Theme, Karolinska University Hospital, Stockholm, Sweden.
Yvonne WengströmDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Eric RullmanDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Helene RundqvistDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. Helene.Rundqvist@ki.se.ORCID http://orcid.org/0000-0002-5617-9076
Karolinska University Hospital · SEKarolinska Institutet · SE

Funding

Cancerfonden 130452Svenska Läkaresällskapet SLS50514Svenska Läkaresällskapet SLS905581
6 · The paper itself

Abstract

backgroundAdjuvant systemic breast cancer treatment improves disease specific outcomes, but also presents with cardiac toxicity. In this post-hoc exploratory analysis of the OptiTrain trial, the effects of exercise on cardiotoxicity were monitored by assessing fitness and biomarkers over the intervention and into survivorship. Methods; Women starting chemotherapy were randomized to 16-weeks of resistance and high-intensity interval training (RT-HIIT), moderate-intensity aerobic and high-intensity interval training (AT-HIIT), or usual care (UC). Outcome measures included plasma troponin-T (cTnT), Nt-pro-BNP and peak oxygen uptake (VO

resultsFor this per-protocol analysis, 88 women met criteria for inclusion. Plasma cTnT increased in all groups post-intervention. At the 1-year follow-up, Nt-pro-BNP was lower in the exercise groups compared to UC. At 2-years there was a drop in VO

conclusionsIn this cohort, high-intensity exercise was associated with lower levels of NT-proBNP 1-year post-baseline, but not with cTnT directly after treatment completion. This may, together with the preserved VO

trial registrationClinicaltrials. govNCT02522260 , Registered 13th of august 2015 - Retrospectively Registered.

Indexed as

BiomarkersCardiotoxicityExercise oncology

Identifiers

PMID33588948
PMCPMC7883413
OpenAlexW3132418454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.