ArticleVeterinary research2021
Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain.
Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- SARS-CoV-2 at the human-pet interface: transmission and pre-existing immunity in pets within infected households.Frontiers in veterinary science · 2026Article
- SARS-CoV-2 animal vaccine with cross-protection against Wuhan strain and delta variant.Scientific reports · 2025Article
- Review
- SARS-CoV-2 infection in animals: Patterns, transmission routes, and drivers.Eco-Environment & Health · 2024Review
- A Comprehensive Study of Cellular and Humoral Immunity in Dogs Naturally Exposed to SARS-CoV-2.Transboundary and emerging diseases · 2024Article
- Neutralizing Antibodies against the SARS-CoV-2 Ancestral Strain and Omicron BA.1 Subvariant in Dogs and Cats in Mexico.Pathogens (Basel, Switzerland) · 2023Article
- First reported cases of SARS-CoV-2 infection in pets in São Paulo, Brazil.Veterinary world · 2022Article
- Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.Veterinary pathology · 2022Article
- Human-to-dog transmission of SARS-CoV-2, Colombia.Scientific reports · 2022Article
- Pulmonary fibrosis in a dog as a sequela of infection with Severe Acute Respiratory Syndrome Coronavirus 2? A case report.BMC veterinary research · 2022Article
- Myocardial Injury Complicated by Systolic Dysfunction in a COVID-19-Positive Dog.Animals : an open access journal from MDPI · 2021Article
- SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay.One health (Amsterdam, Netherlands) · 2021Article
- SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Absence of SARS-CoV-2 Antibodies in Natural Environment Exposure in Sheep in Close Contact with Humans.Animals : an open access journal from MDPI · 2021Article
- SARS-CoV-2 Infections in Animals: Reservoirs for Reverse Zoonosis and Models for Study.Viruses · 2021Review
- SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection.bioRxiv : the preprint server for biology · 2021Article
- COVID Sniffer Dogs: Technical and Ethical Concerns.Frontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by veterinarians in Spain. Therefore, further descriptions of the pathological processes in those animals that show symptoms similar to those described in humans affected by COVID-19 would be highly valuable. The potential for companion animals to contribute to the continued transmission and community spread of this known human-to-human disease is an urgent issue to be considered. Forty animals with pulmonary pathologies were studied by chest X-ray, ultrasound analysis, and computed tomography. Nasopharyngeal and rectal swabs were analyzed to detect canine pathogens, including SARS-CoV-2. An additional twenty healthy dogs living in SARS-CoV-2-positive households were included. Immunoglobulin detection by several immunoassays was performed. Our findings show that sick dogs presented severe alveolar or interstitial patterns with pulmonary opacity, parenchymal abnormalities, and bilateral lesions. The forty sick dogs were negative for SARS-CoV-2 but Mycoplasma spp. was detected in 26 of 33 dogs. Five healthy and one pathological dog presented IgG against SARS-CoV-2. Here we report that despite detecting dogs with α-SARS-CoV-2 IgG, we never obtained a positive RT-qPCR for SARS-SoV-2, not even in dogs with severe pulmonary disease; suggesting that even in the case of canine infection, transmission would be unlikely. Moreover, dogs living in COVID-19-positive households could have been more highly exposed to infection with SARS-CoV-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.