ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2021
Fully quantitative mapping of abnormal aortic velocity and wall shear stress direction in patients with bicuspid aortic valves and repaired coarctation using 4D flow cardiovascular magnetic resonance.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Numerical simulations to predict complication after coarctation repair starting from 4D-Flow magnetic resonance imaging.The international journal of cardiovascular imaging · 2026Article
- 4D Flow Cardiovascular Magnetic Resonance Uncovers the Hemodynamic Clue in Aortic Dissection.JACC. Case reports · 2026Article
- Effects of vessel morphology on aortic hemodynamics: a statistical shape and CFD investigation.Medical & biological engineering & computing · 2026Article
- Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.Journal of magnetic resonance imaging : JMRI · 2025Article
- Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants.The Journal of physiology · 2025Article
- Virtual Therapy Planning of Aortic Valve Replacement for Preventing Patient-Prosthesis Mismatch.Bioengineering (Basel, Switzerland) · 2025Article
- Greater than the sum of its parts: multimodality imaging in adults with congenital heart disease.Cardiovascular diagnosis and therapy · 2024Review
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Assessment of abnormal transvalvular flow and wall shear stress direction for pediatric/young adults with bicuspid aortic valve: A cross-sectional four-dimensional flow study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Non-Invasive Imaging Assessment in Patients with Aortic Coarctation: A Contemporary Review.Journal of clinical medicine · 2023Review
- Coarctation of the Aorta: Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
- Characterization of aortic aging using 3D multi-parametric MRI-long-term follow-up in a population study.Scientific reports · 2023Article
- Article
- Existing and Emerging Approaches to Risk Assessment in Patients with Ascending Thoracic Aortic Dilatation.Journal of imaging · 2022Review
- The role of 4-dimensional flow in the assessment of bicuspid aortic valve and its valvulo-aortopathies.The British journal of radiology · 2022Review
- Wall shear stress and relative residence time as potential risk factors for abdominal aortic aneurysms in males: a 4D flow cardiovascular magnetic resonance case-control study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Combining 4D Flow MRI and Complex Networks Theory to Characterize the Hemodynamic Heterogeneity in Dilated and Non-dilated Human Ascending Aortas.Annals of biomedical engineering · 2021Article
- Aortic displacement and hemodynamics are abnormal in patients with Marfan syndrome: A combined four-dimensional balanced steady-state free precession and four-dimensional flow cardiac magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelices and vortices in thoracic aortic blood flow measured with 4D flow cardiovascular magnetic resonance (CMR) have been associated with aortic dilation and aneurysms. Current approaches are semi-quantitative or when fully quantitative based on 2D plane placement. In this study, we present a fully quantitative and three-dimensional approach to map and quantify abnormal velocity and wall shear stress (WSS) at peak systole in patients with a bicuspid aortic valve (BAV) of which 52% had a repaired coarctation.
methods4D flow CMR was performed in 48 patients with BAV and in 25 healthy subjects at a spatiotemporal resolution of 2.5 × 2.5 × 2.5mm
resultsThe velocity volumes > 120° correlated moderately with the vorticity scores (R ~ 0.50, P < 0.001 for both observers). For WSS surface these results were similar. The velocity volumes between 60° and 120° correlated moderately with LNH (R = 0.66) but the velocity volumes > 120° did not correlate with quantitative vorticity. For abnormal velocity and WSS deviating between 60° and 120°, moderate correlations were found with aortic diameters (R = 0.50-0.70). For abnormal velocity and WSS deviating > 120°, additional moderate correlations were found with age and with peak velocity (stenosis severity) and a weak correlation with gender. Ensemble maps showed that more than 60% of the patients had abnormally directed velocity and WSS. Additionally, abnormally directed velocity and WSS was higher in the proximal descending aorta in the patients with repaired coarctation than in the patients where coarctation was never present.
conclusionThe possibility to reveal directional abnormalities of velocity and WSS in 3D provides a new tool for hemodynamic characterization in BAV disease.
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