Evidence map›Paper›PMID 33588611›Full record

Observational studyDiabetes & vascular disease research

Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study.

Jessica Kearney, Michael Drozd, Andrew Mn Walker, Thomas A Slater, Sam Straw, John Gierula, Maria Paton, Judith Lowry, Charlotte Cole, Klaus K Witte and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jessica KearneyLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0001-7216-4408
Michael DrozdLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Andrew Mn WalkerLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0003-0380-7283
Thomas A SlaterLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0001-9213-5559
Sam StrawLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
John GierulaLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Maria PatonLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Judith LowryLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Charlotte ColeLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Klaus K WitteLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Richard M CubbonLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Mark T KearneyLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Funding

British Heart Foundation FS/12/80/29821British Heart Foundation FS/14/10/30472British Heart Foundation FS/18/44/33792British Heart Foundation FS/CRTF/20/24071
6 · The paper itself

Abstract

introductionWe aimed to evaluate the relationship between temporal changes in renal function and long-term mortality in patients with heart failure with reduced ejection fraction (HFrEF) and identify correlates of deteriorating renal function.

methodsA total of 381 patients with HFrEF enrolled in a prospective cohort study between 2006-2014 had eGFR measured at initial visit and at 1 year. Baseline characteristics were used in a multivariate analysis to establish variables that predict deterioration in eGFR. Follow-up data were used to assess whether declining eGFR was related to outcomes.

resultsPatients were grouped into tertiles based on percentage change in eGFR. In a multivariate logistic regression analysis, male sex was associated with a 1.77-fold ([95% CI 1.01-2.89];

conclusionsIn patients with HFrEF diabetes and male sex are independent predictors of a decline in eGFR at 1 year. A decline eGFR over 1 year is associated with higher long-term all-cause mortality.

Indexed as

Glomerular Filtration RateAgedCause of DeathChronic DiseaseDiabetes MellitusDiabetic NephropathiesDisease ProgressionFemaleHeart FailureHumansKidneyKidney Failure, ChronicMaleMiddle AgedPrognosisProspective StudiesACE-IDiabeteseGFRheart failure

Identifiers

PMID33588611
PMCPMC8481744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.