SynthesisAlcohol and alcoholism (Oxford, Oxfordshire)2022
Digital Interventions for People With Co-Occurring Depression and Problematic Alcohol Use: A Systematic Review and Meta-Analysis.
Synthesis in Alcohol and alcoholism (Oxford, Oxfordshire), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of psychosocial interventions for adults with substance use disorder that have a co-occurring mental health disorder: an umbrella review and illustrative cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2026Pooled it
- Evaluating the evidence: a systematic review of reviews of the effectiveness and safety of digital interventions for ADHD.BMC psychiatry · 2025Pooled it
- Digital Mindfulness Intervention for Pregnant Women With Affective Disorders and Acute Stress Reactions: Prespecified Secondary Analysis of a Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Four-Year Effects of a Computer-Based Brief Alcohol Intervention Targeting Alcohol Users in the General Population: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- eHealth Approaches to Multimorbidity Management: Scoping Review of Interventions and Multidisease Strategies.Online journal of public health informatics · 2026Review
- Implementing digital interventions for co-occurring mental health and alcohol and other drug use problems in health and community settings: a study protocol for the eCliPSE cluster randomised controlled trial.BMC public health · 2025Article
- A Systematic Review of Treatment Approaches for Individuals With Coexisting Diabetes and Substance Use Disorder.Cureus · 2025Review
- Effectiveness of digital interventions for eight mental disorders: A meta-analytic synthesis.Internet interventions · 2025Review
- Digital Integrated Interventions for Comorbid Depression and Substance Use Disorder: Narrative Review and Content Analysis.JMIR mental health · 2025Review
- A Brief Cognitive Behavioral Therapy-Based Digital Intervention for Reducing Hazardous Alcohol Use in South Korea: Development and Prospective Pilot Study.JMIR formative research · 2025Article
- Inclusion of Individuals With Lived Experiences in the Development of a Digital Intervention for Co-Occurring Depression and Cannabis Use: Mixed Methods Investigation.JMIR formative research · 2024Article
- Digital interventions targeting excessive substance use and substance use disorders: a comprehensive and systematic scoping review and bibliometric analysis.Frontiers in psychiatry · 2024Article
- Problematic substance use among patients in a Swedish outpatient psychiatry setting: staff and manager perceptions of digital options for increased intervention access.Addiction science & clinical practice · 2023Article
- Preferences of young adults on the development of a new digital add-on alcohol intervention for depression treatment: A qualitative study.Internet interventions · 2023Article
- Examining differential responses to theAddictive behaviors reports · 2022Article
- Article
- Efficacy of a minimally guided internet treatment for alcohol misuse and emotional problems in young adults: Results of a randomized controlled trial.Addictive behaviors reports · 2021Article
- Randomized controlled trial of online interventions for co-occurring depression and hazardous alcohol consumption: Primary outcome results.Internet interventions · 2021Article
- Effectiveness of a digital alcohol moderation intervention as an add-on to depression treatment for young adults: study protocol of a multicentre pragmatic randomized controlled trial.BMC psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis systematic review and meta-analysis assessed the effectiveness of digital interventions addressing depressive symptoms and alcohol use simultaneously among people with co-occurring depression and problematic alcohol use.
methodsSeven databases were searched for trials evaluating digital interventions aimed at depression and alcohol use. Random-effects meta-analyses were conducted to pool effects on depressive symptoms and alcohol use up to 3-month and 6-month follow-up. Overall quality for every outcome was assessed with GRADE (Grading of Recommendations Assessment, Development and Evaluation).
resultsThe pooled effect of digital interventions compared to their comparators was in favour of digital interventions. Small but significant effects on depressive symptoms at 3-month follow-up were found (g = 0.34, 95% confidence interval (CI): 0.06-0.62, P = 0.02, k = 6) and non-significant effects at 6-month follow-up (g = 0.29, 95% CI: -0.16 to 0.73, P = 0.15, k = 5). For alcohol use, the pooled effect of digital interventions was small and non-significant at 3-month follow-up (g = 0.14, 95% CI: -0.02 to 0.30, P = 0.07, k = 6) and significant at 6-month follow-up (g = 0.14, 95% CI: 0.07-0.20, P = 0.005, k = 5). Sensitivity analysis indicated the latter finding to be sensitive to statistical estimator choice. Quality of evidence was moderate, except for depressive symptoms at 6-month follow-up for which it was low.
conclusionBased on the literature, digital interventions are effective in reducing depressive symptoms at 3-month follow-up and alcohol use at 6-month follow-up among people with comorbid depression and problematic alcohol use. More high-quality trials are needed to confirm the current findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.