ArticleNature2021
CTLA-4 blockade drives loss of T
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 2 pooled it
26.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 2 syntheses or guidelines pooled it, 381 citations in OpenAlex.
- A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation.Nature metabolism · 2023Pooled it
- Transcriptomic datasets of cancer patients treated with immune-checkpoint inhibitors: a systematic review.Journal of translational medicine · 2022Pooled it
- Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial.Nature medicine · 2025Trial
- Blocking PD1 prevents T-cell-promoted fibrosis in myocardial infarction.Cell discovery · 2026Article
- Metal-organic framework nanovaccines for systemic tumour regression.Nature biomedical engineering · 2026Article
- TIF1γ regulates stability of regulatory T cells during inflammation.Nature immunology · 2026Article
- Integrative Omics Analysis Reveals a CD206Barrier immunity · 2026Article
- A lactate-α-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells accelerates tumor progression by inducing NK cell senescence.Nature cancer · 2026Article
- Crosstalk Between CTSBAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Natural-Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti-Tumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular heterogeneity and clonal origin of CCR8Nature communications · 2026Article
- Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges.Apoptosis : an international journal on programmed cell death · 2026Review
- Clinical implications of lactylation modification in digestive system tumors (Review).Oncology letters · 2026Review
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Review
- Poorly perfused tumor regions harbor T cells with a glucose-dependent effector phenotype.EMBO reports · 2026Article
- Costimulation loss enhances IL-2-driven Treg generation by PI3K-STAT3 inhibition in CNS autoimmunity.EMBO molecular medicine · 2026Article
- The Treg-cell death axis in lung cancer: implications for immune evasion and novel therapeutic strategies.Molecular cancer · 2026Review
- ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma.Cell discovery · 2026Article
- Lactate signaling and immune suppression in tumors: mechanisms and therapeutic implications.Cellular oncology (Dordrecht, Netherlands) · 2026Review
192 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byGlucose makes T2021
- Commented on by
- Commented on by
Authors and funding
24 authors at 6 institutions in 2 countries.
Roberta ZappasodiLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA. roz4002@med.cornell.edu.ORCID http://orcid.org/0000-0002-7031-6671
Inna SerganovaWeill Cornell Medicine, New York, NY, USA.
Ivan J CohenDepartment of Neurology, MSK, New York, NY, USA.
Masatomo MaedaDepartment of Neurology, MSK, New York, NY, USA.
Masahiro ShindoDepartment of Neurology, MSK, New York, NY, USA.
Yasin SenbabaogluLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
McLane J WatsonDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Avigdor LeftinDepartment of Medical Physics, MSK, New York, NY, USA.
Rachana ManiyarLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
Svena VermaLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
Matthew LubinDepartment of Neurology, MSK, New York, NY, USA.
Myat KoDepartment of Neurology, MSK, New York, NY, USA.
Mayuresh M ManeDepartment of Neurology, MSK, New York, NY, USA.
Hong ZhongLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
Cailian LiuLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
Arnab GhoshLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
Mohsen Abu-AkeelLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA.
Ellen AckerstaffDepartment of Medical Physics, MSK, New York, NY, USA.
Jason A KoutcherWeill Cornell Medicine, New York, NY, USA.
Ping-Chih HoDepartment of Oncology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-3078-3774
Greg M DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2957-8135
Ronald BlasbergDepartment of Neurology, MSK, New York, NY, USA.
Jedd D WolchokLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA. wolchokj@mskcc.org.ORCID http://orcid.org/0000-0001-6718-2222
Taha MerghoubLudwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA. merghout@mskcc.org.ORCID http://orcid.org/0000-0002-1518-5111
Cornell University · USSwim Across America · USUniversity of Pittsburgh · USKettering University · USLudwig Cancer Research · CHNew York University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTraining in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2MImaging tumor and T cell responses to metabolic and immune modulation therapyR01CA215136 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MERGHOUB, TAHA · 2017 to 2021
$3.8MExploring and exploiting metabolic plasticity in regulatory T cellsDP2AI136598 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2017 to 2017
$2.3MExploiting tumor metabolism to optimize T cell therapyR50CA221810 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Inna Serganova · 2018 to 2026
$1.6MIlluminating metabolic pathways enabled by early T cell activationR21AI135367 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2018 to 2019
$430kLactate transporter MCT1 is required for the high suppressive function of tumor infiltrating regulatory T cellsF31AI149971 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATSON, MCLANE · 2020 to 2021
$86kNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA215136NCI NIH HHS R50 CA221810NCI NIH HHS T32 CA082084NIAID NIH HHS DP2 AI136598NIAID NIH HHS F31 AI149971NIAID NIH HHS R21 AI135367
Abstract
Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T cells
Indexed as
CTLA-4 AntigenGlycolysisNeoplasmsT-Lymphocytes, RegulatoryAnimalsBreast NeoplasmsCell Line, TumorFemaleHumansMammary Neoplasms, ExperimentalMelanomaMiceMice, Inbred BALB CMice, Inbred C57BLCTLA-4 AntigenCTLA4 protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.