Evidence map›Paper›PMID 33588146›Full record

ReviewEuropean journal of cancer (Oxford, England : 1990)2021

Consensus on molecular imaging and theranostics in neuroendocrine neoplasms.

Valentina Ambrosini, Jolanta Kunikowska, Eric Baudin, Lisa Bodei, Catherine Bouvier, Jaume Capdevila, Marta Cremonesi, Wouter W de Herder, Clarisse Dromain, Massimo Falconi and 21 more

Open access · greenAbstract readReviewConsensus Statement
In one paragraph

Review in European journal of cancer (Oxford, England : 1990), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 5 pooled it
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 5 syntheses or guidelines pooled it, 233 citations in OpenAlex.

  1. Pooled it
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  17. Diagnostic Efficacy of FAPI-PET/CT Versus [Diagnostics (Basel, Switzerland) · 2026
    Review
  18. Article
  19. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  20. Review

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 15 countries.

Valentina AmbrosiniIRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy; Nuclear Medicine, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
Jolanta KunikowskaNuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.
Eric BaudinEndocrine Oncolgy Unit, Institut Gustave Roussy, Villejuif Cedex, France.
Lisa BodeiMolecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.
Catherine BouvierInternational Neuroendocrine Cancer Alliance (INCA), Leamington Spa, UK.
Jaume CapdevilaMedical Oncology Department, Vall Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Marta CremonesiRadiation Research Unit, Istituto Europeo di Oncologia, IRCCS, Milano, Italy.
Wouter W de HerderErasmus MC & Erasmus MC Cancer Center, ENETS Center of Excellence Rotterdam, Rotterdam, the Netherlands.
Clarisse DromainLausanne University Hospital, Lausanne, Switzerland.
Massimo FalconiPancreas Translational & Research Institute, Scientific Institute San Raffaele Hospital and University Vita-Salute, Milan, Italy.
Melpomeni FaniDivision of Radiopharmaceutical Chemistry, University Hospital Basel, Basel, Switzerland.
Stefano FantiIRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy; Nuclear Medicine, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
Rodney J HicksThe Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
Levent KabasakalIstanbul University-Cerrahpaşa, Faculty of Medicine, Department of Nuclear Medicine, Turkey.
Gregory KaltsasNational and Kapodistrian University of Athens, Athens, Greece.
Val LewingtonKings College, London, UK.
Silvia MinozziLaboratory of Clinical Research Methodology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Michela CinquiniLaboratory of Clinical Research Methodology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Kjell ÖbergDept of Endocrine Oncology, University Hospital Uppsala, Sweden.
Wim J G OyenHumanitas University and Humanitas Clinical and Research Center, Milan, Italy; Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Radiology and Nuclear Medicine, Rijnstate Hospital Arnhem, the Netherlands.
Dermot O'TooleTrinity College, Dublin, Ireland.
Marianne PavelFriedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Philippe RuszniewskiDepartment of Pancreatology, Beaujon Hospital, Université de Paris, Clichy, France.
Aldo ScarpaARC-NET Centre for Applied Research on Cancer and Department of Pathology, University of Verona, Italy.
Jonathan StrosbergMoffitt Cancer Center, Tampa, FL, USA.
Anders SundinDepartment of Surgical Sciences, Uppsala University, University Hospital, Sweden.
David TaïebDepartment of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, Marseille, France.
Irene VirgoliniDepartment of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Damian WildDivision of Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Ken HerrmannDepartment of Nuclear Medicine, Universitätsklinikum, Essen, Germany. Electronic address: Ken.Herrmann@uk-essen.de.
James YaoGastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Azienda USL di Bologna · ITMario Negri Institute for Pharmacological Research · ITUniversity Hospital of Basel · CHUppsala University Hospital · SEAix-Marseille Université · FRCancer Genomics Centre · NLEssen University Hospital · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHumanitas University · ITInnsbruck Medical University · ATInstitut Gustave Roussy · FRIstanbul University-Cerrahpaşa · TRIstituti di Ricovero e Cura a Carattere Scientifico · ITKing's College London · GBMedical University of Warsaw · PLMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USNational and Kapodistrian University of Athens · GRThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Nuclear medicine plays an increasingly important role in the management neuroendocrine neoplasms (NEN). Somatostatin analogue (SSA)-based positron emission tomography/computed tomography (PET/CT) and peptide receptor radionuclide therapy (PRRT) have been used in clinical trials and approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA). European Association of Nuclear Medicine (EANM) Focus 3 performed a multidisciplinary Delphi process to deliver a balanced perspective on molecular imaging and radionuclide therapy in well-differentiated neuroendocrine tumours (NETs). NETs form in cells that interact with the nervous system or in glands that produce hormones. These cells, called neuroendocrine cells, can be found throughout the body, but NETs are most often found in the abdomen, especially in the gastrointestinal tract. These tumours may also be found in the lungs, pancreas and adrenal glands. In addition to being rare, NETs are also complex and may be difficult to diagnose. Most NETs are non-functioning; however, a minority present with symptoms related to hypersecretion of bioactive compounds. NETs often do not cause symptoms early in the disease process. When diagnosed, substantial number of patients are already found to have metastatic disease. Several societies' guidelines address Neuroendocrine neoplasms (NENs) management; however, many issues are still debated, due to both the difficulty in acquiring strong clinical evidence in a rare and heterogeneous disease and the different availability of diagnostic and therapeutic options across countries. EANM Focus 3 reached consensus on employing

Indexed as

AnimalsHumansMolecular ImagingNeuroendocrine TumorsRadiopharmaceuticalsRadiopharmaceuticalsConsensusMolecular imagingNeuroendocrine neoplasmsPRRT

Identifiers

PMID33588146
PMCPMC8903070
OpenAlexW3133235753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.