ArticleOsteoarthritis and cartilage2021
Quantitative three-dimensional collagen orientation analysis of human meniscus posterior horn in health and osteoarthritis using micro-computed tomography.
Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Histological and immunohistochemical soft-tissue response to cylindrical and concave abutments: Multicenter randomized clinical trial.Journal of periodontology · 2025Trial
- Characterization of calcifications in posterior horn of human meniscus using micro-computed tomography.Osteoarthritis and cartilage open · 2026Article
- Review
- Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis.Biomechanics and modeling in mechanobiology · 2026Article
- Anisotropic wear behavior of meniscus: Influence of cross-shear and loading magnitude.Journal of the mechanical behavior of biomedical materials · 2026Article
- Conceptualization and Preliminary Characterization of Poloxamer-Based Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2025Article
- Histological Analysis of Biological Width and Collagen Fibers Orientation Around Screw-Less, Morse Taper, Hemispherical Base Abutments 8 and 16 Weeks After Implant Uncovering: An Observational Clinical Trial.Dentistry journal · 2025Article
- Structure-property relationships in fibrous meniscal tissue through image-based augmentation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Corneal aberrations are associated with low-energy meniscus injuries.BMC ophthalmology · 2024Observational
- In Situ Loading and Time-Resolved Synchrotron-Based Phase Contrast Tomography for the Mechanical Investigation of Connective Knee Tissues: A Proof-of-Concept Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Revealing the complexity of meniscus microvasculature through 3D visualization and analysis.Scientific reports · 2024Article
- Categorization of collagen type I and II blend hydrogel using multipolarization SHG imaging with ResNet regression.Scientific reports · 2023Article
- Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.International journal of molecular sciences · 2023Article
- 3D analysis and grading of calcifications from ex vivo human meniscus.Osteoarthritis and cartilage · 2023Article
- Early knee OA definition-what do we know at this stage? An imaging perspective.Therapeutic advances in musculoskeletal disease · 2023Review
- Region- and layer-specific investigations of the human menisci using SHG imaging and biaxial testing.Frontiers in bioengineering and biotechnology · 2023Article
- Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells.Biomedicines · 2022Article
- Collagen Remodeling along Cancer Progression Providing a Novel Opportunity for Cancer Diagnosis and Treatment.International journal of molecular sciences · 2022Review
- Structural changes in the collagen network of joint tissues in late stages of murine OA.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveKnee osteoarthritis (OA) is associated with meniscal degeneration that may involve disorganization of the meniscal collagen fiber network. Our aims were to quantitatively analyze the microstructural organization of human meniscus samples in 3D using micro-computed tomography (μCT), and to compare the local microstructural organization between OA and donor samples.
methodWe collected posterior horns of both medial and lateral human menisci from 10 end-stage medial compartment knee OA patients undergoing total knee replacement (medial & lateral OA) and 10 deceased donors without knee OA (medial & lateral donor). Posterior horns were dissected and fixed in formalin, dehydrated in ascending ethanol concentrations, treated with hexamethyldisilazane (HMDS), and imaged with μCT. We performed local orientation analysis of collagenous microstructure in 3D by calculating structure tensors from greyscale gradients within selected integration window to determine the polar angle for each voxel.
resultsIn donor samples, meniscus bundles were aligned circumferentially around the inner border of meniscus. In medial OA menisci, the organized structure of collagen network was lost, and main orientation was shifted away from the circumferential alignment. Quantitatively, medial OA menisci had the lowest mean orientation angle compared to all groups, -24° (95%CI -31 to -18) vs medial donor and -25° (95%CI -34 to -15) vs lateral OA.
conclusionsHMDS-based μCT imaging enabled quantitative analysis of meniscal collagen fiber bundles and their orientations in 3D. In human medial OA menisci, the collagen disorganization was profound with overall lower orientation angles, suggesting collagenous microstructure disorganization as an important part of meniscus degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.