ArticleFree radical biology & medicine2021
A useful and sensitive marker in the prediction of COVID-19 and disease severity: Thiol.
Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Relationship between oxidative stress and COVID-19 severity: A systematic review and meta-analysis.Journal of advanced veterinary and animal research · 2025Article
- Ischemic modified albumin and thiol levels in Coronavirus disease 19: a systematic review and meta-analysis.Diagnostic and prognostic research · 2025Review
- Oxidative Stress Markers and Prediction of Severity With a Machine Learning Approach in Hospitalized Patients With COVID-19 and Severe Lung Disease: Observational, Retrospective, Single-Center Feasibility Study.JMIR formative research · 2025Observational
- Dynamic Thiol-Disulfide Homeostasis Post-COVID-19 Depends on Age, Gender, and Symptom Severity.Cureus · 2024Article
- Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome.Obstetrics & gynecology science · 2024Article
- Reduced IL-8 Secretion by NOD-like and Toll-like Receptors in Blood Cells from COVID-19 Patients.Biomedicines · 2023Article
- Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study.International journal of molecular sciences · 2022Observational
- Value of thiol and ischemia modified albumin (IMA) in predicting mortality in serious COVID-19 pneumonia.Heliyon · 2022Article
- Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection.Irish journal of medical science · 2022Article
- Protection by metformin against severe Covid-19: An in-depth mechanistic analysis.Diabetes & metabolism · 2022Review
- Article
- Predicting the Disease Severity of Virus Infection.Advances in experimental medicine and biology · 2022Article
- Mild Coronavirus Disease 2019 (COVID-19) Is Marked by Systemic Oxidative Stress: A Pilot Study.Antioxidants (Basel, Switzerland) · 2021Article
- Thiol levels in mild or moderate COVID-19 patients: A comparison of variant and classic COVID-19 cases.International journal of clinical practice · 2021Article
- Changes in Serum Thiol-Disulphide Homeostasis in Sheep with Gastrointestinal Nematodes.Animals : an open access journal from MDPI · 2021Article
- Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection.Free radical biology & medicine · 2021Article
- Acute Lung Injury Biomarkers in the Prediction of COVID-19 Severity: Total Thiol, Ferritin and Lactate Dehydrogenase.Antioxidants (Basel, Switzerland) · 2021Article
- Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings.Antioxidants (Basel, Switzerland) · 2021Article
- Oxidative Stress and Inflammatory Biomarkers for the Prediction of Severity and ICU Admission in Unselected Patients Hospitalized with COVID-19.International journal of molecular sciences · 2021Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiol-disulphide homeostasis (TDH) is a new parameter indicating oxidative stress that plays a role in the pathogenesis of various clinical disorders. Our study planned to investigate TDH in COVID-19 patients. Age and gender-matched healthy subjects (n = 70) and COVID-19 patients (n = 144) were included in the study. In addition to the routine laboratory parameters of the groups, their native thiol (NT), total thiol (TT) and disulphide levels were measured. Primarily, we compared COVID-19 patients to the healthy control group for inflammatory parameters, NT, TT and disulphide levels. Then, COVID-19 patients were divided into two groups according to the severity of the disease as mild to moderate and severe COVID-19, and the three groups were compared with each other. Predictive value of thiol parameters in the diagnosis of COVID-19 and in the determining its severity, and its correlation with presence and duration of symptoms were investigated. Severe COVID-19 patients had lower NT and TT levels compared with healthy controls and mild to moderate patients (P < 0.001 for both). The results of ROC analysis show that the greatest AUC was IL-6 and NT (AUC = 0.97, AUC = 0.96, respectively) between control and COVID-19 patients, while it was CRP and NT (AUC = 0.85, AUC = 0.83) between mild to moderate and severe patients. A negative correlation was found between duration of symptoms of dyspnoea, cough, fever, and sore throat and NT (r = -0.45, P = 0.017, r = -0.418, P < 0.001, r = -0.131, P = 0.084, r = -0.452, P = 0.040, respectively). NT and TT levels have a strong predictive value in the diagnosis of COVID-19 and in determining disease severity. Our results support that changing TDH parameters appears to have an important role in disease pathogenesis and it can be used in clinical management of patients.
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