Evidence map›Paper›PMID 33587956›Full record

ReviewProgress in neurobiology2021

Of mice and monkeys: Somatosensory processing in two prominent animal models.

Daniel H O'Connor, Leah Krubitzer, Sliman Bensmaia

Open access · hybridAbstract readReview
In one paragraph

Review in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

  1. Hindlimb Representation in the Spiny Mouse Sensorimotor Cortex.The Journal of comparative neurology · 2026
    Article
  2. A framework for quantifying the mechanics of dexterous grasp.bioRxiv : the preprint server for biology · 2026
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  13. Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. bioRxiv : the preprint server for biology · 2024
    Article
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  20. Prehension kinematics in humans and macaques.Journal of neurophysiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Daniel H O'ConnorSolomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, United States; Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, United States.
Leah KrubitzerDepartment of Psychology and Center for Neuroscience, University of California at Davis, United States.
Sliman BensmaiaDepartment of Organismal Biology and Anatomy, University of Chicago, United States; Committee on Computational Neuroscience, University of Chicago, United States; Grossman Institute for Neuroscience, Quantitative Biology, and Human Behavior, University of Chicago, United States. Electronic address: sliman@uchicago.edu.
Allen Institute for Brain Science · USUniversity of California, Davis · USUniversity of Chicago · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Circuit and cellular dynamics in mouse cortex during tactile detectionR01NS089652 · NINDS · JOHNS HOPKINS UNIVERSITY · PI O'CONNOR, DANIEL HANS · 2014 to 2019
$2.1M
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behaviorR01NS115881 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KRUBITZER, LEAH ANN · 2021 to 2025
$1.9M
NIH HHS P51 OD011107NINDS NIH HHS R01 NS089652NINDS NIH HHS R01 NS104834NINDS NIH HHS R01 NS115881
6 · The paper itself

Abstract

Our understanding of the neural basis of somatosensation is based largely on studies of the whisker system of mice and rats and the hands of macaque monkeys. Results across these animal models are often interpreted as providing direct insight into human somatosensation. Work on these systems has proceeded in parallel, capitalizing on the strengths of each model, but has rarely been considered as a whole. This lack of integration promotes a piecemeal understanding of somatosensation. Here, we examine the functions and morphologies of whiskers of mice and rats, the hands of macaque monkeys, and the somatosensory neuraxes of these three species. We then discuss how somatosensory information is encoded in their respective nervous systems, highlighting similarities and differences. We reflect on the limitations of these models of human somatosensation and consider key gaps in our understanding of the neural basis of somatosensation.

Indexed as

Somatosensory CortexVibrissaeAnimalsHaplorhiniMiceModels, AnimalRatsComparative neuroscienceNeural codingPrimatesProprioceptionRatsTouch

Identifiers

PMID33587956
PMCPMC8096687
OpenAlexW3130416159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.