Evidence map›Paper›PMID 33587949›Full record

ArticleEnvironmental research2021

Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children.

Jennifer K Mann, Liza Lutzker, Stephanie M Holm, Helene G Margolis, Andreas M Neophytou, Ellen A Eisen, Sadie Costello, Tim Tyner, Nina Holland, Gwen Tindula and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Impact of the Wood-BurningEnvironmental health perspectives · 2025
    Trial
  3. Exploratory thresholds for ambient PMBMC public health · 2026
    Article
  4. Article
  5. Article
  6. Pre- and postnatal exposure to PMEnvironmental research · 2026
    Article
  7. Article
  8. Mixture analysis identifies ozone as driving factor for child asthma symptoms.The journal of allergy and clinical immunology. Global · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Examining the Link between Air Quality (PM, SOJournal of clinical medicine · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Jennifer K MannDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Liza LutzkerDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Stephanie M HolmDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Helene G MargolisDepartment of Internal Medicine, University of California, Davis, Davis, CA, USA.
Andreas M NeophytouDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Ellen A EisenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Sadie CostelloDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Tim TynerUniversity of California, San Francisco-Fresno, Fresno, CA, USA; Central California Asthma Collaborative, USA.
Nina HollandDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Gwen TindulaDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Mary PrunickiSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, USA.
Kari NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, USA.
Elizabeth M NothDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Fred LurmannSonoma Technology, Petaluma, CA, USA.
S Katharine HammondDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
John R BalmesDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jbalmes@berkeley.edu.
Berkeley Public Health Division · USUniversity of California, San Francisco · USStanford University · USCenter for Environmental Health · USSonoma Technology (United States) · USUniversity of California, Davis · US

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
UC Berkeley/Stanford Children's Enviromental Health CenterP01ES022849 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R · 2013 to 2018
$4.2M
CHAPS Cohort MaintenanceR24ES030888 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HOLLAND, NINA T · 2020 to 2025
$1.9M
PROJECTED HEAT WAVE MAGNITUDES AND PUBLIC HEALTH IMPACTSRC1ES019073 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARGOLIS, HELENE G · 2009 to 2010
$996k
Air pollution exposures and children's health: mediation and interaction in a counterfactual frameworkR00ES027511 · NIEHS · COLORADO STATE UNIVERSITY · PI NEOPHYTOU, ANDREAS · 2019 to 2022
$747k
Epigenetics of imprinted genes in children with prenatal phthalate exposureF31ES027751 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI TINDULA, GWEN · 2017 to 2018
$89k
NIEHS NIH HHS F31 ES027751NIEHS NIH HHS P01 ES022849NIEHS NIH HHS R00 ES027511NIEHS NIH HHS R24 ES030888NIEHS NIH HHS RC1 ES019073NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

backgroundMetabolic syndrome increases the risk of cardiovascular disease in adults. Antecedents likely begin in childhood and whether childhood exposure to air pollution plays a contributory role is not well understood.

objectivesTo assess whether children's exposure to air pollution is associated with markers of risk for metabolic syndrome and oxidative stress, a hypothesized mediator of air pollution-related health effects.

methodsWe studied 299 children (ages 6-8) living in the Fresno, CA area. At a study center visit, questionnaire and biomarker data were collected. Outcomes included hemoglobin A1c (HbA1c), urinary 8-isoprostane, systolic blood pressure (SBP), and BMI. Individual-level exposure estimates for a set of four pollutants that are constituents of traffic-related air pollution (TRAP) - the sum of 4-, 5-, and 6-ring polycyclic aromatic hydrocarbon compounds (PAH456), NO

resultsThe study population was 53% male, 80% Latinx, 11% Black and largely low-income (6% were White and 3% were Asian/Pacific Islander). HbA1c percentage was associated with longer-term increases in TRAP; for example a 4.42 ng/m DISCUSSION: Our results suggest that both short- and longer-term estimated individual-level outdoor residential exposures to several traffic-related air pollutants, including ambient PAHs, are associated with biomarkers of risk for metabolic syndrome and oxidative stress in children.

Indexed as

Air PollutantsAir PollutionAdultBlood PressureChildEnvironmental ExposureFemaleGlucoseHumansMaleOxidative StressParticulate MatterAir PollutantsGlucoseParticulate MatterChildrenHbA1cMetabolic syndromeOxidative stressPolycyclic aromatic hydrocarbonsTraffic-related air pollution

Identifiers

PMID33587949
PMCPMC8520413
OpenAlexW3131329452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.