Evidence map›Paper›PMID 33587784›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2021

Slower response to treatment of iron-deficiency anaemia in pregnant women infected with HIV: a prospective cohort study.

J C Hull, E M Bloch, C Ingram, R Crookes, J Vaughan, L Courtney, A Jauregui, J F Hilton, E L Murphy, REDS-III South Africa Program

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

J C HullChris Hani Baragwanath Academic Hospital, Soweto, South Africa.
E M BlochJohns Hopkins University School of Medicine, Baltimore, MA, USA.
C IngramNational Bone Marrow Registry, Cape Town, South Africa.
R CrookesCryo-Save Inc., Johannesburg, South Africa.
J VaughanNational Health Laboratory Services, CH Baragwanath Hospital, Soweto, South Africa.
L CourtneyRTI International, Rockville, MA, USA.
A JaureguiStanford University School of Medicine, Stanford, CA, USA.
J F HiltonUniversity of California San Francisco (UCSF), San Francisco, CA, USA.
E L MurphyUniversity of California San Francisco (UCSF), San Francisco, CA, USA.
REDS-III South Africa Program
Chris Hani Baragwanath Hospital · ZACryoLife (United States) · USGerman National Bone Marrow Donor Registry · DEJohns Hopkins Medicine · USNational Health Laboratory Service · ZARTI International · USStanford University · USUniversity of California, San Francisco · USVitalant · US

Funding

Research training in HIV-related transfusion medicine and hematology in South AfricaD43TW010345 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI UTE JENTSCH, EDWARD L MURPHY · 2017 to 2026
$3.0M
The Malaria Transfusion Risk (MATRix) StudyK23HL151826 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BLOCH, EVAN MARTIN · 2020 to 2024
$882k
FIC NIH HHS D43 TW010345National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health for the Recipient Epidemiology and Donor Evaluation Study-III International program HHSN2682011-00001INational Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health for the Recipient Epidemiology and Donor Evaluation Study-III International program K23-HL151826NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS K23 HL151826WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002C
6 · The paper itself

Abstract

objectiveAntenatal anaemia is associated with increased peripartum transfusion requirement in South Africa. We studied whether HIV was associated with the response to treatment of iron-deficiency anaemia.

designProspective cohort study.

settingHospital-based antenatal anaemia clinic in South Africa. SAMPLE: Equal-sized cohorts of pregnant women testing positive for HIV (HIV+) and testing negative for HIV (HIV-) with iron-deficiency anaemia.

methodsHaemoglobin trajectories of women with confirmed iron-deficiency anaemia (ferritin < 50 ng/ml) were estimated from the initiation of iron supplementation using mixed-effects modelling, adjusted for baseline HIV status, ferritin level, maternal and gestational ages and time-varying iron supplementation.

main outcome measuresHaemoglobin trajectories.

resultsOf 469 women enrolled, 51% were HIV+, 90% of whom were on antiretroviral therapy (with a mean CD4+ lymphocyte count of 403 cells/mm

conclusionsCompared with women who were HIV-, women who were HIV+ with iron-deficiency anaemia had slower but successful haemoglobin recovery with iron therapy. Earlier effective management of iron deficiency could reduce the incidence of peripartum blood transfusion. TWEETABLE ABSTRACT: Among pregnant women with iron-deficiency anaemia in South Africa, HIV slows haemoglobin recovery in response to oral iron therapy.

Indexed as

HIV InfectionsPregnancy Complications, InfectiousPrenatal CareAdministration, IntravenousAdministration, OralAdolescentAdultAnemia, Iron-DeficiencyCohort StudiesCross-Sectional StudiesFemaleHumansIronMiddle AgedPregnancyPregnancy Complications, HematologicIronHIVIron-deficiency anaemiapregnancy

Identifiers

PMID33587784
PMCPMC8364561
OpenAlexW3130663305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.