ArticleACS sensors2021
High-Speed Lens-Free Holographic Sensing of Protein Molecules Using Quantitative Agglutination Assays.
Article in ACS sensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Universal Nanopore Sensor for Amplification-Free and Label-Free Detection of Molecular Biomarkers.ACS sensors · 2025Article
- Unsupervised Learning-Assisted Acoustic-Driven Nano-Lens Holography for the Ultrasensitive and Amplification-Free Detection of Viable Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Digital in-line holographic microscopy for label-free identification and tracking of biological cells.Military Medical Research · 2024Review
- Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence.Nature communications · 2023Review
- Point-of-care SARS-CoV-2 sensing using lens-free imaging and a deep learning-assisted quantitative agglutination assay.Lab on a chip · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
Accurate, cost-effective, easy-to-use, and point-of-care sensors for protein biomarker levels are important for disease diagnostics. A cost-effective and compact readout approach that has been used for several diagnostic applications is lens-free holographic microscopy, which provides an ultralarge field of view and submicron resolution when it is coupled with pixel super-resolution techniques. Despite its potential as a diagnostic technique, lens-free microscopy has not previously been applied to quantitative protein molecule sensing in solution, which can simplify sensing protocols and ultimately enable measurements of binding kinetics in physiological conditions. Here, we sense interferon-γ (an immune system biomarker) and NeutrAvidin molecules in solution by combining lens-free microscopy with a one-step bead-based agglutination assay, enabled by a custom high-speed light-emitting diode (LED) array and automated image processing routines. We call this a quantitative large-area binding (QLAB) sensor. The high-speed light source provides, for the first time, pixel super-resolved imaging of >10
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Registered trials
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