Evidence map›Paper›PMID 33587607›Full record

ArticleACS nano2021

High-Throughput Peptide Derivatization toward Supramolecular Diversification in Microtiter Plates.

Yiyang Lin, Matthew Penna, Christopher D Spicer, Stuart G Higgins, Amy Gelmi, Nayoung Kim, Shih-Ting Wang, Jonathan P Wojciechowski, E Thomas Pashuck, Irene Yarovsky and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Peptide modificationChemical science · 2026
    Article
  2. Click/release reaction and SONature communications · 2026
    Article
  3. Review
  4. 3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels.Chemistry of materials : a publication of the American Chemical Society · 2024
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Yiyang LinDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0001-8572-649X
Matthew PennaSchool of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.
Christopher D SpicerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0001-8787-578X
Stuart G HigginsDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0002-4653-5364
Amy GelmiDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
Nayoung KimDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
Shih-Ting WangDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0002-7634-8332
Jonathan P WojciechowskiDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
E Thomas PashuckDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0003-2881-4965
Irene YarovskySchool of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.ORCID 0000-0002-4033-5150
Molly M StevensDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0002-7335-266X
Imperial College London · GBKarolinska Institutet · SERMIT University · AU

Funding

Medical Research Council MR/R015651/1Wellcome Trust
6 · The paper itself

Abstract

The evolution of life on earth eventually leads to the emergence of species with increased complexity and diversity. Similarly, evolutionary chemical space exploration in the laboratory is a key step to pursue the structural and functional diversity of supramolecular systems. Here, we present a powerful tool that enables rapid peptide diversification and employ it to expand the chemical space for supramolecular functions. Central to this strategy is the exploitation of palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to direct combinatorial synthesis of peptide arrays in microtiter plates under an open atmosphere. Taking advantage of this

Indexed as

PalladiumPeptidesHydrogelsHydrogelsPalladiumPeptidescombinatorial synthesishigh-throughput screeningpeptideself-assemblySuzuki−Miyaura cross coupling

Identifiers

PMID33587607
PMCPMC7992134
OpenAlexW3131536246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.