Evidence map›Paper›PMID 33587237›Full record

ReviewNeurochemical research2022

Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters.

Claudia Alleva, Jan-Philipp Machtens, Daniel Kortzak, Ingo Weyand, Christoph Fahlke

Open access · hybridAbstract readReview
In one paragraph

Review in Neurochemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  12. Frontiers in physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claudia Alleva *Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.
Jan-Philipp Machtens *Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.
Daniel KortzakInstitute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.
Ingo WeyandInstitute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.
Christoph FahlkeInstitute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany. c.fahlke@fz-juelich.de.ORCID http://orcid.org/0000-0001-8602-9952
Forschungszentrum Jülich · DE

Funding

Verein Deutscher Ingenieure FA 301/12-2Verein Deutscher Ingenieure MA 7525/1-2
6 · The paper itself

Abstract

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After its release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by excitatory amino acid transporters (EAATs) 1-5, a subfamily of glutamate transporters. The five proteins utilize a complex transport stoichiometry that couples glutamate transport to the symport of three Na

Indexed as

Amino Acid Transport System X-AGGlutamic AcidAnimalsAnionsBiological TransportExcitatory Amino Acid Transporter 1Glutamate Plasma Membrane Transport ProteinsMammalsAmino Acid Transport System X-AGAnionsExcitatory Amino Acid Transporter 1Glutamate Plasma Membrane Transport ProteinsGlutamic AcidConformational selectionCoupled transportDual function proteinEAAT anion channelFluorescence spectroscopyGltPhGlutamate transporterHairpin 2Induced fitMD simulationsTransport stoichiometryTryptophan

Identifiers

PMID33587237
PMCPMC8763778
OpenAlexW3133421318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.