ArticleNeuroradiology2021
Altered cerebral perfusion in response to chronic mild hypercapnia and head-down tilt Bed rest as an analog for Spaceflight.
Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest.Experimental physiology · 2026Article
- Automated behavioral segmentation and markerless pose tracking of mice during spaceflight.bioRxiv : the preprint server for biology · 2026Article
- A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies.NPJ microgravity · 2025Article
- Spaceflight Standard Measures is a multidisciplinary study that systematically monitors risks to astronaut health and performance.NPJ microgravity · 2025Review
- Review of microgravity's impact on cardiovascular and nervous systems in space exploration.NPJ microgravity · 2025Review
- Ophthalmic changes are associated with visual cortex functional network reorganization after 90-day head-down tilt bed rest.Quantitative imaging in medicine and surgery · 2025Article
- Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): a systematic review.NPJ microgravity · 2025Article
- Long-term effects of simulated microgravity in the central nervous system of rhesus monkeys: a voxel-wise multimodal MRI study.Frontiers in physiology · 2025Article
- Multimodal Imaging-Based Cerebral Blood Flow Prediction Model Development in Simulated Microgravity.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Cerebrovascular autoregulation in hypoxia: quantitative insights from arterial spin labeling.Frontiers in neuroscience · 2025Review
- Artificial gravity: an effective countermeasure for microgravity-induced headward fluid shift?Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog.AJNR. American journal of neuroradiology · 2023Article
- External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial.NPJ microgravity · 2023Article
- Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity.Communications biology · 2023Article
- Reply to Wostyn et al.: Potential models for perivascular space (PVS) enlargement and spaceflight-associated neuro-ocular syndrome (SANS).Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization.Human brain mapping · 2021Article
- Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome.Frontiers in neurology · 2021Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeFollowing prolonged stays on the International Space Station (ISS), some astronauts exhibit visual acuity changes, ophthalmological findings, and mildly elevated intracranial pressures as part of a novel process called spaceflight-associated neuro-ocular syndrome (SANS). To determine the pathophysiology of SANS, NASA conducted a multi-investigator study in which 11 healthy participants underwent head-down tilt bed rest, mimicking microgravity-induced cephalad fluid shifts, combined with elevated ambient CO
methodsUsing arterial spin labeling, we compared cerebral perfusion before, during, and after HDT+CO
resultsAll participants demonstrated a decrease in perfusion during HDT+CO2 (mean decrease of 25.1% at HDT7 and 16.2% at HDT29); however, the timing and degree of change varied between the groups. At day 7 of HDT+CO
conclusionCompared with baseline and recovery, HDT+CO
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.