ArticleUrolithiasis2021
Exploring mechanisms of protein influence on calcium oxalate kidney stone formation.
Article in Urolithiasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Unveiling potential natural promoters of calcium oxalate kidney stones in the urine via anion-exchange chromatography, crystal assays, and proteomics.Molecular and cellular biochemistry · 2026Article
- Article
- Promoting Effects of Urinary Proteins from Stone Formers and Influence of Their Physicochemical Properties on Calcium Oxalate Kidney Stone Formation.Computational and structural biotechnology journal · 2026Article
- Anion exchange chromatographic fractionation of urinary proteins followed by tandem mass spectrometry identifies potential natural inhibitors of calcium oxalate stone.Computational and structural biotechnology journal · 2025Article
- Impact of diet on renal stone formation.Journal of family medicine and primary care · 2024Review
- Comparison of cat stone matrix and cat urine proteomes to human calcium oxalate stone matrix and urine proteomes.Urolithiasis · 2024Article
- Pathophysiology and Main Molecular Mechanisms of Urinary Stone Formation and Recurrence.International journal of molecular sciences · 2024Review
- Comparison of cat and human calcium oxalate monohydrate kidney stone matrix proteomes.Urolithiasis · 2022Article
- Do outcomes of ureteroscopic stone treatment vary with stone composition? A prospective analysis.Central European journal of urology · 2022Article
- Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions.PloS one · 2022Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Calcium oxalate monohydrate (COM) crystals are the primary constituent of most kidney stones, but urine proteins in stone matrix are believed to be critical elements for stone formation from these crystals. Recent data have shown that hundreds of proteins appear in the stone matrix with no explanation for inclusion of so many proteins. We have proposed a stone formation model with protein stimulated COM aggregation based on polyanion-polycation aggregation, which is supported by finding that matrix is highly enriched in strongly anionic and strongly cationic proteins. Many other proteins may be drawn to such aggregates due to their limited solubility in water or charge effects. Finding similar protein enrichment in both polyarginine (pR) induced aggregates of urine proteins and COM stone matrix would support this hypothesis. Purified proteins (PP) were obtained from random urine samples of six healthy adults by ultradiafiltration. Protein aggregation was induced by adding pR to PP solutions at two concentrations; 0.25 and 0.5 µg pR/µg of PP. Samples of each fraction and the original PP mixture were lyophilized and analyzed by tandem mass spectrometry. Aggregates induced by pR addition to PP samples collected a protein mixture that mimicked the protein distribution observed in COM matrix, supporting our hypothesis. The apparently discordant behavior of certain abundant anionic proteins preferentially joining the pR aggregate, when they had demonstrated reduced abundance in COM stone matrix, suggests that this model was overdriven to aggregate. The reversal of aggregate preference of albumin at low pR addition supports this interpretation.
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