Evidence map›Paper›PMID 33587040›Full record

ArticleeLife2021

Bardet-Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome.

Yan-Xia Liu, Bin Xue, Wei-Yue Sun, Jenna L Wingfield, Jun Sun, Mingfu Wu, Karl F Lechtreck, Zhenlong Wu, Zhen-Chuan Fan

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. RABL2 promotes the outward transition zone passage of signaling proteins in cilia via ARL3.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Review
  8. Article
  9. Unraveling the intricate cargo-BBSome coupling mechanism at the ciliary tip.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Appearing and disappearing acts of cilia.Journal of biosciences · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Click chemistry-enabled CRISPR screening reveals GSK3 as a regulator of PLD signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. UsingGenes · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan-Xia Liu *State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Bin Xue *State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Wei-Yue SunState Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Jenna L WingfieldDepartment of Cellular Biology, University of Georgia, Athens, United States.
Jun SunState Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Mingfu WuDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, United States.
Karl F LechtreckDepartment of Cellular Biology, University of Georgia, Athens, United States.
Zhenlong WuState Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China.
Zhen-Chuan FanState Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin, China.ORCID 0000-0003-1712-3413

Funding

Signaling by beta 1 integrins regulates ventricular wall morphogenesis and compactionR01HL121700 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu, YANG Kevin XIANG · 2015 to 2026
$5.4M
Regulation of protein transport in ciliaR01GM110413 · NIGMS · UNIVERSITY OF GEORGIA · PI LECHTRECK, KARL · 2014 to 2022
$2.7M
NHLBI NIH HHS R01 HL121700NIGMS NIH HHS R01 GM110413
6 · The paper itself

Abstract

Certain ciliary signaling proteins couple with the BBSome, a conserved complex of Bardet-Biedl syndrome (BBS) proteins, to load onto retrograde intraflagellar transport (IFT) trains for their removal out of cilia in

Indexed as

ADP-Ribosylation FactorsChlamydomonas reinhardtiiCiliaFlagellaPhospholipase DProtein TransportADP-Ribosylation FactorsPhospholipase DBBS3BBSomecell biologychlamydomonas reinhardtiiciliaintraflagellar transportphospholipase D

Identifiers

PMID33587040
PMCPMC7963478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.