Evidence map›Paper›PMID 33586914›Full record

ArticleBirth defects research2021

Causes of neonatal and postneonatal death among infants with birth defects in Texas.

Renata H Benjamin, Jason L Salemi, Mark A Canfield, Wendy N Nembhard, Cecilia Ganduglia Cazaban, KuoJen Tsao, Anthony Johnson, A J Agopian

Open access · greenAbstract read
In one paragraph

Article in Birth defects research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Renata H BenjaminDepartment of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, Texas, USA.ORCID 0000-0001-6406-4247
Jason L SalemiCollege of Public Health and Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-0077-6023
Mark A CanfieldBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas, USA.
Wendy N NembhardDepartment of Epidemiology, Fay W. Boozman College of Public Health and Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-8318-4049
Cecilia Ganduglia CazabanDepartment of Management, Policy, and Community Health, UTHealth School of Public Health, Houston, Texas, USA.
KuoJen TsaoDepartment of Pediatric Surgery, McGovern Medical School at UTHealth and Children's Memorial Hermann Hospital, Houston, Texas, USA.
Anthony JohnsonDepartment of Pediatric Surgery, McGovern Medical School at UTHealth and Children's Memorial Hermann Hospital, Houston, Texas, USA.
A J AgopianDepartment of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, Texas, USA.ORCID 0000-0002-5874-4155
University of Texas Health Science Center at Dallas · USMemorial Hermann · USBaylor College of Medicine · USTexas Department of State Health Services · USUniversity of Arkansas for Medical Sciences · US

Funding

RFA-DD-18-001 Birth Defects Study To Evaluate Pregnancy exposures (BD-STEPS) II Core & Component B Steps -StillbirthU01DD001285 · DD · UNIV OF ARKANSAS FOR MED SCIS · PI NEMBHARD, WENDY N · 2019 to 2022
$5.2M
Do Cesarean Deliveries Reduce Mortality in Infants with Birth Defects?R01HD086120 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI AGOPIAN, A.J. · 2016 to 2017
$383k
ACL HHS U01DD001285NCBDD CDC HHS U01 DD001285NCBDD CDC HHS U01DD001285NICHD NIH HHS R01 HD086120
6 · The paper itself

Abstract

backgroundThe proportion of deaths attributed to various causes has not been quantified among infants with birth defects. We sought to describe the causes of neonatal and postneonatal death among infants in the Texas Birth Defects Registry.

methodsWe calculated frequencies and percentages for both underlying causes and all causes (underlying or contributing) of neonatal (0-27 days) and postneonatal (28-364 days) death listed on death certificates among infants born alive with birth defects and delivered in Texas during 1999-2013 (n = 8,389 deaths). Analyses were repeated separately for infants with isolated, multiple, and syndromic defects.

resultsAfter birth defects, the most frequently listed causes of neonatal death were preterm/low birth weight (10%), circulatory system diseases (8%), and sepsis (5%). The leading postneonatal causes of death beyond birth defects were circulatory system diseases (32%), sepsis (11%), and renal failure (7%).

conclusionsImproved understanding of the causes of mortality among infants with birth defects may help identify priorities for postnatal care. Our results suggest that potentially modifiable causes of death (e.g., circulatory system diseases, sepsis) contribute substantially to mortality in this population. Prioritizing continued improvements in prevention, diagnosis, and management of preventable conditions may reduce mortality among infants born with birth defects.

Indexed as

Infant, Low Birth WeightInfant MortalityHumansInfantInfant, NewbornRegistriesRisk FactorsTexasbirth defectscause of deathepidemiologyinfant mortalityregistries

Identifiers

PMID33586914
PMCPMC8920027
OpenAlexW3129687391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.