Evidence map›Paper›PMID 33586912›Full record

ArticleInfluenza and other respiratory viruses2021

The COVID-19 epidemic in Madagascar: clinical description and laboratory results of the first wave, march-september 2020.

Rindra Vatosoa Randremanana, Soa-Fy Andriamandimby, Jean Marius Rakotondramanga, Norosoa Harline Razanajatovo, Reziky Tiandraza Mangahasimbola, Tsiry Hasina Randriambolamanantsoa, Hafaliana Christian Ranaivoson, Harinirina Aina Rabemananjara, Iony Razanajatovo, Richter Razafindratsimandresy and 20 more

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Pooled it
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  16. Full GenomeFrontiers in public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 3 countries.

Rindra Vatosoa RandremananaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Soa-Fy AndriamandimbyVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Jean Marius RakotondramangaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.ORCID 0000-0003-0490-7665
Norosoa Harline RazanajatovoVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Reziky Tiandraza MangahasimbolaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Tsiry Hasina RandriambolamanantsoaVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Hafaliana Christian RanaivosonVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Harinirina Aina RabemananjaraVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Iony RazanajatovoVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Richter RazafindratsimandresyVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Joelinotahiana Hasina RabarisonVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Cara E BrookUniversity of California Berkeley, Berkeley, CA, USA.
Fanjasoa RakotomananaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Roger Mario RabetombosoaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Helisoa RazafimanjatoVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Vida AhyongChan Zuckerberg Biohub, San Francisco, CA, USA.
Vololoniaina RaharinosyVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Vaomalala RaharimangaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Sandratana Jonhson RaharinantoaninaVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Mirella Malala RandrianarisoaEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Barivola BernardsonEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Laurence RandrianasoloEpidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Léa Bricette Nirina RandriamampiononaMinistry of Public Health, Government of the Republic of Madagascar, Antananarivo, Madagascar.
Cristina M TatoChan Zuckerberg Biohub, San Francisco, CA, USA.
Joseph L DeRisiChan Zuckerberg Biohub, San Francisco, CA, USA.
Philippe DussartVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.ORCID 0000-0002-1931-3037
Manuela Christophère VololoniainaMinistry of Public Health, Government of the Republic of Madagascar, Antananarivo, Madagascar.
Fidiniaina Mamy RandriatsarafaraMinistry of Public Health, Government of the Republic of Madagascar, Antananarivo, Madagascar.
Zely Arivelo RandriamanantanyMinistry of Public Health, Government of the Republic of Madagascar, Antananarivo, Madagascar.
Jean-Michel HeraudVirology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.ORCID 0000-0003-1107-0859
Institut Pasteur · FRInstitut Pasteur de Madagascar · MGChan Zuckerberg Initiative (United States) · USUniversity of California, Berkeley · US

Funding

Sustaining Surveillance Networks and Response to Seasonal and Pandemic Influenza U51IP000812 · IP · PASTEUR INSTITUTE FROM MADAGASCAR · PI HERAUD, JEAN-MICHEL · 2013 to 2015
$1.5M
NCIRD CDC HHS U51 IP000812NCIRD CDC HHS U5/IP000812-05World Health Organization
6 · The paper itself

Abstract

backgroundFollowing the first detection of SARS-CoV-2 in passengers arriving from Europe on 19 March 2020, Madagascar took several mitigation measures to limit the spread of the virus in the country.

methodsNasopharyngeal and/or oropharyngeal swabs were collected from travellers to Madagascar, suspected SARS-CoV-2 cases and contact of confirmed cases. Swabs were tested at the national reference laboratory using real-time RT-PCR. Data collected from patients were entered in an electronic database for subsequent statistical analysis. All distribution of laboratory-confirmed cases were mapped, and six genomes of viruses were fully sequenced.

resultsOverall, 26,415 individuals were tested for SARS-CoV-2 between 18 March and 18 September 2020, of whom 21.0% (5,553/26,145) returned positive. Among laboratory-confirmed SARS-CoV-2-positive patients, the median age was 39 years (IQR: 28-52), and 56.6% (3,311/5,553) were asymptomatic at the time of sampling. The probability of testing positive increased with age with the highest adjusted odds ratio of 2.2 [95% CI: 1.9-2.5] for individuals aged 49 years and more. Viral strains sequenced belong to clades 19A, 20A and 20B indicative of several independent introduction of viruses.

conclusionsOur study describes the first wave of the COVID-19 in Madagascar. Despite early strategies in place Madagascar could not avoid the introduction and spread of the virus. More studies are needed to estimate the true burden of disease and make public health recommendations for a better preparation to another wave.

Indexed as

AdultAsymptomatic InfectionsCOVID-19COVID-19 Nucleic Acid TestingEpidemiological MonitoringFemaleGenome, ViralHumansMadagascarMaleMiddle AgedNasopharynxSARS-CoV-2TravelCOVID-19epidemiologymadagascarpandemicSARS-CoV-2Surveillance

Identifiers

PMID33586912
PMCPMC8013501
OpenAlexW3133126828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.