ArticleHead & neck2021
Low-risk human papilloma virus positive oropharyngeal cancer with one positive lymph node: Equivalent outcomes in patients treated with surgery and radiation therapy versus surgery alone.
Reilly A Sample, Carey Burton Wood, Angela L Mazul, Thomas F Barrett, Randal C Paniello, Jason T Rich, Stephen Y Kang, Jose Zevallos, Mackenzie D Daly, Wade L Thorstad and 4 more
Abstract readClinical Study
In one paragraphArticle in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Reilly A SampleDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0001-5830-5083 Carey Burton WoodDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
Angela L MazulDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
Thomas F BarrettDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0002-6058-1404 Randal C PanielloDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
Jason T RichDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
Stephen Y KangDepartment of Otolaryngology - Head and Neck Surgery, The James Cancer Hospital, Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-0865-6149 Jose ZevallosDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0002-9111-6767 Mackenzie D DalyDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
Wade L ThorstadDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0002-2757-0543 Stephanie Y ChenDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0002-1244-7462 Patrik PipkornDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
Ryan S JacksonDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0003-4626-2324 Sidharth V PuramDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0003-3543-889X Funding
Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5MDEVELOPMENT OF CLINICIAN/RESEARCHERS IN ACADEMIC ENTT32DC000022 · NIDCD · WASHINGTON UNIVERSITY · PI PICCIRILLO, JAY F. · 1989 to 2022
$5.6MUnderstanding programs of invasion and metastasis in head and neck cancerK08CA237732 · NCI · WASHINGTON UNIVERSITY · PI PURAM, SIDHARTH VENKATA · 2019 to 2023
$984kIntegrating social and molecular determinants of HPV-associated cancersK01MD013897 · NIMHD · WASHINGTON UNIVERSITY · PI MAZUL, ANGELA LIU · 2020 to 2023
$519kNCATS NIH HHS TL1 TR002344NCI NIH HHS K08 CA237732NIDCD NIH HHS T32 DC000022NIMHD NIH HHS K01 MD013897
6 · The paper itselfAbstract
backgroundFor human papilloma virus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), management recommendations for patients with a single metastatic lymph node <6 cm in diameter remain nebulous, leading to treatment heterogeneity in this common subgroup of patients.
methodsWe utilized the National Cancer Database to perform survival and multivariable analyses of patients with HPV+ OPSCC with one positive lymph node <6 cm and negative surgical margins.
resultsWe found that 5-year survival is comparable between patients who receive surgery and adjuvant radiation versus surgery alone. In multivariable analyses, we found no significant difference in the hazard ratio of overall survival after adjusting for various potential confounders.
conclusionsThese data suggest that patients with margin-negative HPV+ OPSCC with a single positive lymph node <6 cm have comparable survival with or without adjuvant radiation. Future studies exploring outcomes for this specific group in randomized-controlled trials will be critical for further evaluating these initial observations.
Indexed as
Carcinoma, Squamous CellHead and Neck NeoplasmsOropharyngeal NeoplasmsPapillomavirus InfectionsHumansLymph NodesPapillomaviridaede-escalationhead and neck cancerHPVoropharyngeal cancerradiation
Identifiers
PMID33586842
PMCPMC8106657
What OpenQuestion holds
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