Evidence map›Paper›PMID 33586470›Full record

ArticleJournal of the American Heart Association2021

Yoshiki Shinya, Takahiro Hiraide, Mizuki Momoi, Shinichi Goto, Hisato Suzuki, Yoshinori Katsumata, Yutaka Kurebayashi, Jin Endo, Motoaki Sano, Keiichi Fukuda and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Interstitial Lung Disease in Immunocompromised Children.Diagnostics (Basel, Switzerland) · 2022
    Article
  4. Article
  5. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  6. Article
  7. Article
  8. Journal of the American Heart Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yoshiki ShinyaDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Takahiro HiraideDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Mizuki MomoiDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Shinichi GotoDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Hisato SuzukiCenter for Medical Genetics Keio University School of Medicine Tokyo Japan.
Yoshinori KatsumataDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Yutaka KurebayashiInstitute for Integrated Sports Medicine Keio University School of Medicine Tokyo Japan.
Jin EndoDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Motoaki SanoDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Keiichi FukudaDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Kenjiro KosakiCenter for Medical Genetics Keio University School of Medicine Tokyo Japan.
Masaharu KataokaDepartment of Cardiology Keio University School of Medicine Tokyo Japan.
Keio University · JPSuzuki (Japan) · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Recently, some studies reported the pulmonary artery hypertension (PAH)-associated genes. However, a majority of patients with familial or sporadic PAH lack variants in the known pathogenic genes. In this study, we investigated the new causative gene variants associated with PAH. Methods and Results Whole-exome sequencing in 242 Japanese patients with familial or sporadic PAH identified a heterozygous substitution change involving c.226G>A (p.Gly76Ser) in tumor necrotic factor receptor superfamily 13B gene (

Indexed as

Genetic Predisposition to DiseaseMutationAdultDNAExomeExome SequencingFemaleHumansMalePedigreePulmonary Arterial HypertensionTransmembrane Activator and CAML Interactor ProteinDNATNFRSF13B protein, humanTransmembrane Activator and CAML Interactor Proteingeneticspulmonary arterial hypertensionstructural analysisTNFRSF13Bwhole‐exome sequencing

Identifiers

PMID33586470
PMCPMC8174299
OpenAlexW3130327238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.