ArticleProblemy endokrinologii2021
Correlation of in vitro fertilization (IVF) infertility treatment outcomes and body weight index in women of reproductive age.
Article in Problemy endokrinologii, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Nomogram to predict the probability of clinical pregnancy in women with poor ovarian response undergoing in vitro fertilization/ intracytoplasmic sperm injection cycles.Archives of gynecology and obstetrics · 2024Article
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Abstract
Backgraund: obesity/overweight in women are often the causes of menstrual dysfunction and infertility.
aimsTo identify the association between overweight/obesity and IVF outcomes. MATERIALS AND
methodsretrospective study - data of 1874 patients undergoing IVF in the Endocrinology Research Centre (2012-2019) was analyzed. EXCLUSION CRITERIA: BMI <18.5 kg/m2, polycystic ovary syndrome, donation of -oocytes, ectopic pregnancy, fertilization with partner's epididymal/testicular sperm. The study included 1583 women aged 21-45 years (median 33.0 y.o. [30.0; 37.0], median BMI 23 kg/m2 [20.7; 26.2]). Statistical data processing was performed using the STATISTICA application package (StatSoft). The threshold level of statistical significance is <0.05.
resultsPatients were divided into 5 groups (gr.): normal body weight (NBW) - 1061 people (ppl.) (gr. 1), overweight - 368 (gr. 2), class I obesity - 117 (gr. 3), class II obesity - 36 (gr. 4), class III obesity - 1 (gr. 5). In each group, the estimated pregnancy rate (PR) and its outcomes, the frequency of lightweight newborns (body weight at birth <2500g), newborns with NBW (2500-3999g), births with a large fetus (≥4000g) were measured. The PR didn't differ: 34.6%, 34.5%, 30,7%, 41,7%, respectively, the woman in gr.5 got pregnant. Among 407 (74.4%) singleton pregnancies urgent delivery was registered in 71.91%, 67,57%, 70,83%, 60,0%, gr. 5 - no -information. Premature birth: 7,66%, 5,41%, 8,33%, 0%. Spontaneous abortion in the 1st trimester: 18,30%, 25,68%, 20,83%, 40,0%. Spontaneous abortion in the 2nd trimester: 2,13%, 1,35% in gr. 2, 3, 4. Lightweight newborns: 8,81%, 11,36%, 6,25%, 0%. Newborns with NBW: 84,91%, 84,09%, 75,0%, 60,0%. Large-childbirth - 6,29%, 4,55%, 18,75%, 40,0%.
conclusionsCorrelation analysis of the dependence of PR and its outcomes on the BMI was not revealed (p=0.975 and p=0.469, respectively). Large fetus births were more often detected in obese patients (p=0.0016). A large prospective group is needed to expand the estimated body parameters to the IVF outcomes.
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