ArticleCancer medicine2021
Changing trends in the disease burden of esophageal cancer in China from 1990 to 2017 and its predicted level in 25 years.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 2 of them syntheses that pooled it.
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Who cites it
125 citing papers in PubMed, 2 syntheses or guidelines pooled it, 262 citations in OpenAlex.
- PD-1 inhibitors in advanced esophageal squamous cell carcinoma: a survival analysis of reconstructed patient-level data.Frontiers in pharmacology · 2024Pooled it
- Pooled it
- Global burden of esophageal cancer attributable to smoking and alcohol, 1990-2021, with projections to 2040: a population-based analysis of the global burden of disease study 2021.Annals of medicine · 2026Observational
- Global, regional, and national burden of maternal hemorrhage from 1990 to 2021, with projections to 2050: Insights from the Global Burden of Disease Study 2021.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Global, Regional, and National Burden of Caries Among Women of Childbearing Age From 1990 to 2021 and Prediction.International dental journal · 2026Article
- Comparative analysis of early-onset and late-onset esophageal cancer burden in China, 1990-2021: based on the 2021 Global Burden of Disease Study.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Alcohol Consumption and Age-Specific Risk of Esophageal Cancer: Prospective Cohort Study.JMIR public health and surveillance · 2026Article
- Development and internal validation of a prognostic model for esophageal cancer liver metastases using the Surveillance, Epidemiology, and End Results database.Journal of thoracic disease · 2026Article
- Bayesian model prediction of colorectal cancer incidence in Jiangsu Province, China, a cancer registry-based study.BMC public health · 2026Article
- The burden and trends of late-onset multiple sclerosis, Parkinson's disease, Alzheimer's disease and other dementias among adults aged 55 and older, spanning from 1990 to 2021, with projections through 2050.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Epidemiology of esophageal cancer in Xiamen, China, 2011-2020: trends in incidence, mortality, and survival from a population-based registry study.Cancer causes & control : CCC · 2026Article
- Global Inequality and Future Burden of Autism Spectrum Disorders: A Frontier and Projection Analysis Based on GBD 2021.Brain and behavior · 2026Article
- Global burden, risk factors and projections of self-harm mortality in adults aged 65+ years: A 60-year trend analysis from the Global Burden of Disease Study 2021.General psychiatry · 2026Article
- The palmitoylation enzyme ZDHHC2 promotes esophageal cancer progression via N-acetylaspartylglutamate.Discover oncology · 2026Article
- Trends, patterns, and risk factors of esophageal cancer mortality in China, 2008-2021: A National Mortality Surveillance System data analysis.Journal of advanced research · 2026Article
- Global Burden of Type 2 Diabetes Attributable to Behavioral Risks: Insights and Projections to 2050 Based on the Global Burden of Disease Study 2021.International journal of public health · 2026Article
- Recent findings on the global, regional, and national burden of lower extremity peripheral arterial disease in the elderly (1990-2021): an analysis based on the global burden of disease study 2021.Frontiers in cardiovascular medicine · 2026Article
- The global disease burden and associated risk factors of age-related macular degeneration: a comprehensive analysis.International ophthalmology · 2025Article
- Perioperative outcomes following neoadjuvant immunochemotherapy in elderly patients with locally advanced esophageal squamous cell carcinoma.The Journal of international medical research · 2025Article
- Temporal trends in gender, etiology, severity and outcomes of acute pancreatitis in a third-tier Chinese city from 2013 to 2021.Annals of medicine · 2025Article
65 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNearly half of the cases of esophageal cancer in the world were in China, but the corresponding burden in China has not been estimated for the past decades or for the near future.
methodsData on the incidence, mortality, and disability-adjusted life years (DALYs) rates owing to esophageal cancer in China from 1990 to 2017 were extracted from the Global Burden of Disease Study 2017. To reflect the trend in the disease burden, we calculated the estimated annual percentage change (EAPC) in the age-standardized rates of these three outcomes in China from 1990 to 2017.
resultsThe age-standardized incidence rate (ASIR) for esophageal cancer decreased from 19.38/100,000 in 1990 to 12.23/100,000 in 2017, with an EAPC of -2.53 (95%CI: -2.90, -2.16), but the number of cases of esophageal cancer increased from 164,473 to 234,624. The age-standardized rates of esophageal cancer in females were always lower than they were in males during the study period, and there was a downward trend that was more pronounced among females than males. The most common risk factors for males were smoking and alcohol consumption, while the most common risk factors for females were a diet low in fruits and a high body mass index (BMI). New cases of, and deaths from esophageal cancer are predicted to increase by about 1.5 times in the coming 25 years.
conclusionAlthough the age-standardized burden of esophageal cancer has been declining, the number of new cases of, and deaths from esophageal cancer have increased in China over the past 30 years, and they will continue to increase in the near future. Hence, national policies should be adopted to promote the prevention and management of known risk factors for it, especially smoking and excessive caloric intake.
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