Evidence map›Paper›PMID 33586319›Full record

ArticleAustralasian journal on ageing2021

Trends in anticholinergic and opioid dispensing in older adults from 2004 to 2015: Results from the Personality and Total Health (PATH) Through Life Study.

Malinee Neelamegam, Janice Zgibor, Henian Chen, Kathleen O'Rourke, Chighaf Bakour, Lakshminarayan Rajaram, Kaarin J Anstey

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Article in Australasian journal on ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Malinee NeelamegamYale School of Public Health, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-4027-7544
Janice ZgiborCollege of Public Health, University of South Florida, Tampa, FL, USA.
Henian ChenCollege of Public Health, University of South Florida, Tampa, FL, USA.
Kathleen O'RourkeCollege of Public Health, University of South Florida, Tampa, FL, USA.
Chighaf BakourCollege of Public Health, University of South Florida, Tampa, FL, USA.ORCID https://orcid.org/0000-0002-0096-2870
Lakshminarayan RajaramCollege of Public Health, University of South Florida, Tampa, FL, USA.
Kaarin J AnsteyCentre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, ACT, Australia.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Endeavour Research FellowshipFIC NIH HHS D43 TW010540National Health and Medical Research Council 1002160National Health and Medical Research Council 179805National Health and Medical Research Council 418039National Institutes of Health, Fogarty International CenterNHMRC Research Fellowship 1102694NINDS NIH HHS D43TW010540
6 · The paper itself

Abstract

objectiveDue to potential adverse effects, guidelines recommend that anticholinergics and opioids be avoided in older adults unless necessary. This study examines the dispensing trends of these medications among older Australians.

methodsData of 2222 PATH study (60+ cohort) participants were analysed. Medication dispensing data were obtained from the Pharmaceutical Benefits Scheme from April 2004 to March 2015. Temporal trends of prescriptions dispensed were assessed using joinpoint regression analysis.

resultsOf all dispensed prescriptions, 5.5% were for anticholinergics and opioids, and 46.2% of anticholinergics dispensed were anti-depressants. Anticholinergic dispensing trend increased in 2004-2015 (annual per cent change, APC = 3.4%), particularly for moderately anticholinergic medications (APC = 6.8%). Dispensing trend for opioids increased in 2004-2011 (APC = 11.3%) and declined in 2011-2015 (APC = -4.4%).

conclusionWhile guidelines urge caution in prescribing these medications to older adults, dispensing increased over time in this study population.

Indexed as

Analgesics, OpioidCholinergic AntagonistsAgedAustraliaDrug PrescriptionsHumansPersonalityPractice Patterns, Physicians'Analgesics, OpioidCholinergic Antagonistsagedcholinergic antagonistopioid analgesics

Identifiers

PMID33586319
PMCPMC12107022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.