ArticleJournal of evolutionary biology2021
Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.
Article in Journal of evolutionary biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses.Molecular biology and evolution · 2024Article
- Investigating the outcomes of virus coinfection within and across host species.PLoS pathogens · 2023Article
- Heterogeneities in infection outcomes across species: sex and tissue differences in virus susceptibility.Peer community journal · 2023Article
- Between virus correlations in the outcome of infection across host species: Evidence of virus by host species interactions.Evolution letters · 2021Article
- Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.Journal of evolutionary biology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The likelihood of a successful host shift of a parasite to a novel host species can be influenced by environmental factors that can act on both the host and parasite. Changes in nutritional resource availability have been shown to alter pathogen susceptibility and the outcome of infection in a range of systems. Here, we examined how dietary protein to carbohydrate altered susceptibility in a large cross-infection experiment. We infected 27 species of Drosophilidae with an RNA virus on three food types of differing protein to carbohydrate ratios. We then measured how viral load and mortality across species was affected by changes in diet. We found that changes in the protein:carbohydrate in the diet did not alter the outcomes of infection, with strong positive inter-species correlations in both viral load and mortality across diets, suggesting no species-by-diet interaction. Mortality and viral load were strongly positively correlated, and this association was consistent across diets. This suggests changes in diet may give consistent outcomes across host species, and may not be universally important in determining host susceptibility to pathogens.
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