Evidence map›Paper›PMID 33586116›Full record

ArticleOral and maxillofacial surgery2021

Influence of the cumulative effect of zoledronic acid on periodontal microcirculation in rats.

G A Kosach, A L Petrosyan, A I Yaremenko, S I Kutukova, A A Zubareva, S G Chefu, T D Vlasov

Abstract read
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Article in Oral and maxillofacial surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

G A KosachFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022. german1kosach@gmail.com.ORCID http://orcid.org/0000-0002-1135-4678
A L PetrosyanFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.
A I YaremenkoFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.ORCID https://orcid.org/0000-0002-7700-7724
S I KutukovaFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.ORCID https://orcid.org/0000-0003-2221-4088
A A ZubarevaFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.
S G ChefuFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.
T D VlasovFirst Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.ORCID https://orcid.org/0000-0002-6951-7599
First Pavlov State Medical University of St. Petersburg · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of repeated administration of zoledronic acid (ZA) on the development and severity of osteonecrosis of the jaws.

methodsIn the experiment, 36 rats were used, which were divided into 4 groups: group 1 was injected with saline for 6 weeks, group 2 was injected with ZA once, group 3 was injected zoledronic acid for 3 weeks once a week, group 4 was injected with ZA for 6 weeks once a week. While taking medications, the tooth was removed. The volumetric blood flow rate was studied using laser and high-frequency ultrasound Doppler in the area of the periodontium of an extracted tooth in rats with the application of acetylcholine. Bone tissue was examined out using CBCT.

resultsIn group 2, there was a violation of blood flow in the mucous membrane, bone microcirculation, but no reliable data was obtained in the bone defect in comparison with group 1. In groups 3 and 4, there was significantly disrupted blood flow. This led to an increase of the osteonecrosis (maximum at the 4th group), which was confirmed by data obtained using CBCT. An inverse relationship was observed between the blood flow of bone tissue and the size of the defect after tooth extraction.

conclusionThe introduction of ZA in a dose-dependent fashion resulted in impaired endothelial vasodilation and impaired blood flow to extraction sockets. These findings might explain the development of osteonecrosis of the mandible following removal of a first molar.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsAnimalsDiphosphonatesMicrocirculationRatsTooth ExtractionZoledronic AcidBone Density Conservation AgentsDiphosphonatesZoledronic AcidBisphosphonatesBRONJDoppler ultrasonographyEndothelial dysfunctionMRONJZoledronic acid

Identifiers

PMID33586116
OpenAlexW3132420721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.