ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021
Decreased classical monocytes and CD163 expression in TB patients: an indicator of drug resistance.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Hematological Profiles of Pulmonary Tuberculosis and Multi-Drug-Resistant Tuberculosis Patients at Debre Tabor Comprehensive Specialized Hospital, North-Central Ethiopia: A Comparative Cross-Sectional Study.Health science reports · 2026Article
- ASAP1 as a novel dual-level biomarker for tuberculosis: integrated genetic and proteomic evidence for early detection and disease monitoring.Molecular biology reports · 2026Article
- Early innate cell interactions withFrontiers in immunology · 2023Review
- SLC11A1 genetic variation and low expression may cause immune response impairment in TB patients.Genes and immunity · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
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Abstract
Tuberculosis (TB) is a disease instigated by Mycobacterium tuberculosis. Peripheral blood monocytes represent highly efficient effector cells of innate immunity against TB. Little is known about monocyte subsets and their potential involvement in the development of M. tuberculosis drug resistance in patients with TB. This study was conducted to investigate alterations in monocyte subsets, CD163 expression on monocytes, and its serum level in patients without and with rifampicin resistance TB (RR-TB) and healthy controls. A total of 164 patients with TB (84 without RR-TB and 80 patients with RR-TB) and 85 healthy controls were enrolled in this study. The percentages of various monocyte subsets and surface expression of CD163 on monocytes were quantitatively determined using flow cytometry. The serum level of CD163 was determined by commercially available ELISA kits. Decreased frequency of classical monocytes was detected in patients with RR-TB. Non-classical monocytes were decreased in patients without RR-TB; however, intermediate monocytes were raised in patients with RR-TB. The serum level of CD163 was decreased in patients of RR-TB that showsed a positive correlation with the frequency of CD14
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