Evidence map›Paper›PMID 33586039›Full record

ArticleAmino acids2021

Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women.

Matheus Uba Chupel, Luciele Guerra Minuzzi, Guilherme Eustáquio Furtado, Mário Leonardo Santos, José Pedro Ferreira, Edith Filaire, Ana Maria Teixeira

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05149716 (Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05149716 nacompletednot on this map

Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years

TypeinterventionalSponsorUniversity of Sao PauloRan2020 to 2020Enrolled24ConditionsOxidative StressArmsTaurine, Placebo
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Matheus Uba ChupelFaculty of Sport Science and Physical Education, Research Center for Sport and Physical Activity, CIDAF, University of Coimbra, Coimbra, Portugal. matheusuba@hotmail.com.ORCID http://orcid.org/0000-0003-3295-0919
Luciele Guerra MinuzziFaculty of Sport Science and Physical Education, Research Center for Sport and Physical Activity, CIDAF, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0002-9342-5563
Guilherme Eustáquio FurtadoFaculty of Sport Science and Physical Education, Research Center for Sport and Physical Activity, CIDAF, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0001-8327-1567
Mário Leonardo SantosFaculty of Sport Science and Physical Education, Research Center for Sport and Physical Activity, CIDAF, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0001-9148-9697
José Pedro FerreiraFaculty of Sport Science and Physical Education, Research Center for Sport and Physical Activity, CIDAF, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0002-4427-3276
Edith FilaireCIAMS Laboratory, EA 4532, University of Paris-Sud, University of Orléans, Orléans, France.ORCID http://orcid.org/0000-0002-5127-7486
Ana Maria TeixeiraFaculty of Sport Science and Physical Education, Research Center for Sport and Physical Activity, CIDAF, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0003-3762-7192
University of Coimbra · PTEscola Superior de Enfermagem de Coimbra · PTUniversidade Paulista · BRUniversité Paris-Sud · FR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 11929-13/8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 13642-13/8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 1417/3-4Fundação para a Ciência e a Tecnologia PTDC/DTP-DES/0154/2012
6 · The paper itself

Abstract

Immunosenescence contributes to cognitive impairment and neurodegeneration, and those conditions could be attenuated by non-pharmacological anti-inflammatory strategies, such as exercise and supplementation with the amino acid taurine. Since taurine body content decreases with aging, we investigated the effects of supplementation (alone and combined with exercise) on oxidative stress, extracellular matrix degradation, white blood cells, neurotrophins, cognition and physical fitness of elderly women. Forty-eight women (83.58 ± 6.98 years) were enrolled into exercise training only (EO: n = 13), taurine supplementation (TS: n = 12), exercise training + taurine supplementation (ETTS: n = 11), and control group (CG: n = 12). All interventions lasted 14 weeks. Exercise was applied twice a week, and taurine was given once a day (1.5 g). Data collection occurred before and after interventions with the determination of myeloperoxidase (MPO), matrix metalloproteinase-9 (MMP-9), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) levels, and white blood cell counts (WBC). Montreal cognitive assessment (MoCA) and physical fitness tests were also evaluated. Concentration of MPO and MMP-9 decreased after intervention in TS (p < 0.05). No effect of time or time × group was observed for WBC parameters; however, univariate analysis showed a significant decrease in lymphocytes for TS, while an increase in monocytes occurred in the CG (p < 0.05). MoCA scores decreased over time in the CG (p < 0.05). Improvements in physical fitness occurred in ETTS (better agility and aerobic capacity), mostly likely due to exercise and boosted by taurine supplementation. No changes in BDNF levels were observed (p > 0.05), while NGF concentration were undetectable in almost subjects. Exercise together with taurine supplementation appears to be a valuable strategy to enhance health-related outcomes in older persons.

Indexed as

Dietary SupplementsAgedAged, 80 and overAgingCognitionExerciseFemaleHumansLeukocyte CountMatrix Metalloproteinase 9Mental Status and Dementia TestsPeroxidasePhysical FitnessTaurineMatrix Metalloproteinase 9MMP9 protein, humanMPO protein, humanPeroxidaseTaurineAgingCognitionExerciseImmunityOxidative stressTaurine

Identifiers

PMID33586039
OpenAlexW3133217249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.