Evidence map›Paper›PMID 33585963›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

First-in-human neuroimaging of soluble epoxide hydrolase using [

Jennifer M Coughlin, Stephanie Slania, Yong Du, Laura K Shinehouse, Mary Katherine Brosnan, Babak Behnam Azad, Daniel P Holt, Hong Fan, Wojciech G Lesniak, Il Minn and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. [European journal of nuclear medicine and molecular imaging · 2023
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jennifer M Coughlin *Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Stephanie Slania *Biomedical Engineering, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Yong Du *Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Laura K ShinehouseRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Mary Katherine BrosnanRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Babak Behnam AzadRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Daniel P HoltRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Hong FanRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Wojciech G LesniakRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Il MinnRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Steven P RoweRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Robert F DannalsRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Andrew G HortiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Martin G PomperDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA. mpomper@jhmi.edu.ORCID 0000-0001-6753-3010
Johns Hopkins University · US

Funding

PET imaging of soluble epoxide hydrolase (sEH) in human subjectsR33AG054802 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2019 to 2020
$1.1M
PET imaging of soluble epoxide hydrolase (sEH) in human subjectsR21AG054802 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2017 to 2018
$569k
NIA NIH HHS R21 AG054802NIA NIH HHS R33 AG054802
6 · The paper itself

Abstract

purposeSoluble epoxide hydrolase (sEH) is an enzyme with putative effect on neuroinflammation through its influence on the homeostasis of polyunsaturated fatty acids and related byproducts. sEH is an enzyme that metabolizes anti-inflammatory epoxy fatty acids to the corresponding, relatively inert 1,2-diols. A high availability or activity of sEH promotes vasoconstriction and inflammation in local tissues that may be linked to neuropsychiatric diseases. We developed [

methodsBrain PET using bolus injection of [

results[

conclusionThese data support further use of [

Indexed as

Epoxide HydrolasesPositron-Emission TomographyAdultBrainFemaleHumansMaleMiddle AgedNeuroimagingEpoxide HydrolasesMolecular imagingNeuroinflammationNeuropsychiatricPositron emission tomographysEH

Identifiers

PMID33585963
PMCPMC10129439
OpenAlexW3130668764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.