Evidence map›Paper›PMID 33585956›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Brain interstitial glycerol correlates with evolving brain injury in paediatric traumatic brain injury.

Nqobile S Thango, Ursula K Rohlwink, Lindizwe Dlamini, M Phophi Tshavhungwe, E Banderker, Shamiel Salie, J M N Enslin, Anthony A Figaji

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. An update on pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nqobile S ThangoDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.
Ursula K RohlwinkDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.
Lindizwe DlaminiDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.
M Phophi TshavhungweDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.
E BanderkerDepartment of Radiology, University of Cape Town, Cape Town, South Africa.
Shamiel SaliePaediatric Intensive Care Unit, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
J M N EnslinDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.
Anthony A FigajiDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa. anthony.figaji@uct.ac.za.ORCID http://orcid.org/0000-0002-3357-6490
University of Cape Town · ZA

Funding

Medical Research Council MR/P028071/1
6 · The paper itself

Abstract

purposeA better understanding of the complex pathophysiology of traumatic brain injury (TBI) is needed to improve our current therapies. Cerebral microdialysis (CMD) is an advanced method to monitor the brain, but little is known about its parameters in children. Brain glycerol, one of the CMD variables, is an essential component of the phospholipid bilayer cell membrane and is considered a useful marker of tissue hypoxia in adults. This study examined the time course of glycerol and its associations in paediatric TBI.

methodsIn this retrospective cohort study, we collected data on children (< 13years) with severe TBI who underwent CMD monitoring. The relationship of glycerol was examined with respect to physiological, radiological variables, and clinical outcome.

resultsTwenty-eight children underwent CMD monitoring and had evaluable data. Lesion progression on head computed tomography (CT) demonstrated a strong relationship with glycerol (median glycerol, maximum and initial-to-maximum) when lesion size increased by > 30% (p=0.01, p=0.04 and p=0.004). Absolute glycerol values had a weak but statistically significant association with intracranial pressure and brain oxygenation. We did not find an association with clinical outcome.

conclusionThis is the first study to provide data on brain interstitial glycerol in children. CMD glycerol, particularly an increase from baseline, is associated with other markers of injury and with a significant increase in lesion size on repeat head CT. As such, it may represent a useful monitorable marker for evolving injury in paediatric TBI.

Indexed as

Brain InjuriesBrain Injuries, TraumaticAdultBrainChildGlycerolHumansRetrospective StudiesGlycerolCerebral microdialysisChildrenGlycerolHead computed tomographyTraumatic brain injury

Identifiers

PMID33585956
OpenAlexW3133350015

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.