Evidence map›Paper›PMID 33585763›Full record

ArticleACS omega2021

Macrophage-Engineered Vesicles for Therapeutic Delivery and Bidirectional Reprogramming of Immune Cell Polarization.

Khaga R Neupane, J Robert McCorkle, Timothy J Kopper, Jourdan E Lakes, Surya P Aryal, Masud Abdullah, Aaron A Snell, John C Gensel, Jill Kolesar, Christopher I Richards

Abstract read
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Engineering of Cell Derived-Nanovesicle as an Alternative to Exosome Therapy.Tissue engineering and regenerative medicine · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Khaga R NeupaneDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
J Robert McCorkleDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40508, United States.
Timothy J KopperSpinal Cord and Brain Injury Research Center, Department of Physiology University of Kentucky, Lexington, Kentucky 40536, United States.
Jourdan E LakesDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Surya P AryalDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Masud AbdullahDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Aaron A SnellDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
John C GenselSpinal Cord and Brain Injury Research Center, Department of Physiology University of Kentucky, Lexington, Kentucky 40536, United States.
Jill KolesarDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40508, United States.
Christopher I RichardsDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

Funding

Contributions of Myelin Derived Arachidonic Acid to Macrophage Polarization and Secondary Damage after Spinal Cord InjuryF31NS105443 · NINDS · UNIVERSITY OF KENTUCKY · PI KOPPER, TIMOTHY JOSEPH · 2018 to 2020
$90k
NINDS NIH HHS F31 NS105443
6 · The paper itself

Abstract

Macrophages, one of the most important phagocytic cells of the immune system, are highly plastic and are known to exhibit diverse roles under different pathological conditions. The ability to repolarize macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) or

Identifiers

PMID33585763
PMCPMC7876833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.