ArticleERJ open research2021
Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma.
Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06068309 (Perception, Adherence, Clinical, Economical and Health-Related Quality of Life Outcomes of CareAide® App Usage in Chronic Diseases), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perception, Adherence, Clinical, Economical and Health-Related Quality of Life Outcomes of CareAide® App Usage in Chronic Diseases
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Adverse Outcomes Associated With Short-Acting Beta-Agonist Overuse in Asthma: A Systematic Review and Meta-Analysis.Allergy · 2025Pooled it
- The Adherence Paradox in Uncontrolled Moderate-To-Severe Asthma: A Qualitative Study of Patient Experiences and Unmet Needs.Research in nursing & health · 2026Article
- Adherence to asthma medication and asthma control in Finland.BMC pulmonary medicine · 2026Article
- Smoking and Lung Function Response to Inhaled Glucocorticoids in Adult-Onset Asthma.Journal of asthma and allergy · 2026Article
- Adherence to Inhaled Corticosteroids and Inflammatory Phenotypes in Asthma.Journal of asthma and allergy · 2026Article
- Best practice advice for asthma exacerbation prevention and management in primary care: an international expert consensus.NPJ primary care respiratory medicine · 2024Review
- Asthma prescribing trends, inhaler adherence and outcomes: a Real-World Data analysis of a multi-ethnic Asian Asthma population.NPJ primary care respiratory medicine · 2024Article
- Documentation of comorbidities, lifestyle factors, and asthma management during primary care scheduled asthma contacts.NPJ primary care respiratory medicine · 2024Article
- An Analysis of Medication Adherence in a Large Outpatient Population During the COVID-19 Pandemic Using a Novel Value-Based Pharmacy System.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2024Article
- Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach.Current allergy and asthma reports · 2023Review
- Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program.American journal of respiratory and critical care medicine · 2023Article
- Lung Function and Asthma Clinical Control in N-ERD Patients, Three-Year Follow-Up in the Context of Real-World Evidence.Journal of asthma and allergy · 2023Article
- Defined daily dose definition in medication adherence assessment in asthma.European clinical respiratory journal · 2023Article
- Adherence to inhaled corticosteroids in relation to quality of life and symptoms of anxiety and depression in asthma.European clinical respiratory journal · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn short-term studies, poor adherence to inhaled corticosteroids (ICS) has been associated with worse asthma control, but the association of long-term adherence and disease control remains unclear.
objectiveTo assess the relationship between 12-year adherence to ICS and asthma control in patients with adult-onset asthma.
methodsAs part of the Seinäjoki Adult Asthma Study, 181 patients with clinically confirmed new-onset adult asthma and regular ICS medication were followed-up for 12 years. Adherence (%) to ICS was assessed individually ((µg dispensed/µg prescribed)×100) during the follow-up. Asthma control was evaluated after 12 years of treatment according to the Global Initiative for Asthma 2010 guideline.
resultsAsthma was controlled in 31% and not controlled (partly controlled or uncontrolled) in 69% of the patients. Patients with not-controlled asthma were more often male, older, nonatopic and used higher doses of ICS than those with controlled disease. The mean±sd 12-year adherence to ICS was 63±38% in patients with controlled asthma and 76±40% in patients with not-controlled disease (p=0.042). Among patients with not-controlled asthma, those with lower 12-year adherence (<80%) had more rapid decline in forced expiratory volume in 1 s (-47 mL·year
conclusionsIn adult-onset asthma, patients with not-controlled disease showed better 12-year adherence to ICS treatment than those with controlled asthma. In not-controlled disease, adherence <80% was associated with more rapid lung function decline, underscoring the importance of early recognition of such patients in routine clinical practice.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.