Evidence map›Paper›PMID 33585535›Full record

ReviewFrontiers in nutrition2020

The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes.

Amira Kohil, Maha Al-Asmakh, Mashael Al-Shafai, Annalisa Terranegra

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. A2 milk consumption and its health benefits: an update.Food science and biotechnology · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Diabetes: discovery of insulin, genetic, epigenetic and viral infection mediated regulation.The Nucleus : an international journal of cytology and allied topics · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amira KohilDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Maha Al-AsmakhDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Mashael Al-ShafaiDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Annalisa TerranegraResearch Branch, Sidra Medicine, Doha, Qatar.
Qatar University · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex disease due to the interaction between genetic and environmental factors. Certain dietary patterns and nutrients are known to cause epigenetic modifications in physiological conditions and diseases. However, the interplay between diet and epigenetics is not yet well-understood in the context of T1DM. Several studies have described epigenetic mechanisms involved in the autoimmune reactions that destroy the β-cells, but few explored diet components as potential triggers for epigenetic modifications. Clarifying the link between diet and epigenome can provide new insights into the pathogenesis of T1DM, potentially leading to new diagnostic and therapeutic approaches. In this mini review, we shed light on the influence of the diet-epigenome axis on the pathophysiology of T1DM.

Indexed as

dietDNA methylationepigeneticshistone modificationsmicro-RNAtype 1 diabetes

Identifiers

PMID33585535
PMCPMC7876257
OpenAlexW3127983507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.