ReviewFrontiers in cell and developmental biology2020
The Lung Vasculature: A Driver or Passenger in Lung Branching Morphogenesis?
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Morphological and molecular aspects of lung development.Histology and histopathology · 2025Review
- Early Pulmonary Hypertension in Preterm Infants.Clinics in perinatology · 2024Review
- The lung mesenchyme in development, regeneration, and fibrosis.The Journal of clinical investigation · 2023Review
- Development and Disorders of the Airway in Bronchopulmonary Dysplasia.Children (Basel, Switzerland) · 2023Review
- Simple Models of Lung Development.Advances in experimental medicine and biology · 2023Article
- Enhancement of airway epithelial cell differentiation by pulmonary endothelial cell co-culture.Stem cell research · 2022Article
- Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes.Life science alliance · 2022Article
- Article
- Lung volume determination by dual-source computed tomography in infants with pulmonary artery sling: a case-control study.Translational pediatrics · 2022Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Multiple cellular, biochemical, and physical factors converge to coordinate organogenesis. During embryonic development, several organs such as the lung, salivary glands, mammary glands, and kidneys undergo rapid, but intricate, iterative branching. This biological process not only determines the overall architecture, size and shape of such organs but is also a pre-requisite for optimal organ function. The lung, in particular, relies on a vast surface area to carry out efficient gas exchange, and it is logical to suggest that airway branching during lung development represents a rate-limiting step in this context. Against this background, the vascular network develops in parallel to the airway tree and reciprocal interaction between these two compartments is critical for their patterning, branching, and co-alignment. In this mini review, we present an overview of the branching process in the developing mouse lung and discuss whether the vasculature plays a leading role in the process of airway epithelial branching.
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Registered trials
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